METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

Yuqin Wang; Ming Gao; Fuxing Zhu; Xinzhi Li; Ying Yang; Qiuxin Yan; Linna Jia; Liwei Xie; Zheng Chen

doi:10.1038/s41467-020-15488-2

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

Yuqin Wang
, Ming Gao
, Fuxing Zhu
, Xinzhi Li
, Ying Yang
, Qiuxin Yan
, Linna Jia
, Liwei Xie
, Zheng Chen^*

^*Corresponding author for this work

School of Life Science and Technology, Harbin Institute of Technology
Northeast Normal University
Guangdong Academy of Sciences

Research output: Contribution to journal › Article › peer-review

124 Scopus citations

Abstract

Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that METTL3 (a key RNA methyltransferase) expression increases significantly in interscapular brown adipose tissue (iBAT) after birth and plays an essential role in the postnatal development and maturation of iBAT. BAT-specific deletion of Mettl3 severely impairs maturation of BAT in vivo by decreasing m⁶A modification and expression of Prdm16, Pparg, and Ucp1 transcripts, which leads to a marked reduction in BAT-mediated adaptive thermogenesis and promotes high-fat diet (HFD)-induced obesity and systemic insulin resistance. These data demonstrate that METTL3 is an essential regulator that controls iBAT postnatal development and energy homeostasis.

Original language	English
Article number	1648
Journal	Nature Communications
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-15488-2
State	Published - 1 Dec 2020
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice",

abstract = "Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that METTL3 (a key RNA methyltransferase) expression increases significantly in interscapular brown adipose tissue (iBAT) after birth and plays an essential role in the postnatal development and maturation of iBAT. BAT-specific deletion of Mettl3 severely impairs maturation of BAT in vivo by decreasing m6A modification and expression of Prdm16, Pparg, and Ucp1 transcripts, which leads to a marked reduction in BAT-mediated adaptive thermogenesis and promotes high-fat diet (HFD)-induced obesity and systemic insulin resistance. These data demonstrate that METTL3 is an essential regulator that controls iBAT postnatal development and energy homeostasis.",

author = "Yuqin Wang and Ming Gao and Fuxing Zhu and Xinzhi Li and Ying Yang and Qiuxin Yan and Linna Jia and Liwei Xie and Zheng Chen",

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doi = "10.1038/s41467-020-15488-2",

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T1 - METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

AU - Wang, Yuqin

AU - Gao, Ming

AU - Zhu, Fuxing

AU - Li, Xinzhi

AU - Yang, Ying

AU - Yan, Qiuxin

AU - Jia, Linna

AU - Xie, Liwei

AU - Chen, Zheng

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that METTL3 (a key RNA methyltransferase) expression increases significantly in interscapular brown adipose tissue (iBAT) after birth and plays an essential role in the postnatal development and maturation of iBAT. BAT-specific deletion of Mettl3 severely impairs maturation of BAT in vivo by decreasing m6A modification and expression of Prdm16, Pparg, and Ucp1 transcripts, which leads to a marked reduction in BAT-mediated adaptive thermogenesis and promotes high-fat diet (HFD)-induced obesity and systemic insulin resistance. These data demonstrate that METTL3 is an essential regulator that controls iBAT postnatal development and energy homeostasis.

AB - Brown adipose tissue (BAT) undergoes rapid postnatal development and then protects against cold and obesity into adulthood. However, the molecular mechanism that determines postnatal development and maturation of BAT is largely unknown. Here we show that METTL3 (a key RNA methyltransferase) expression increases significantly in interscapular brown adipose tissue (iBAT) after birth and plays an essential role in the postnatal development and maturation of iBAT. BAT-specific deletion of Mettl3 severely impairs maturation of BAT in vivo by decreasing m6A modification and expression of Prdm16, Pparg, and Ucp1 transcripts, which leads to a marked reduction in BAT-mediated adaptive thermogenesis and promotes high-fat diet (HFD)-induced obesity and systemic insulin resistance. These data demonstrate that METTL3 is an essential regulator that controls iBAT postnatal development and energy homeostasis.

UR - https://www.scopus.com/pages/publications/85083041435

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DO - 10.1038/s41467-020-15488-2

M3 - 文章

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AN - SCOPUS:85083041435

SN - 2041-1723

VL - 11

JO - Nature Communications

JF - Nature Communications

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ER -

METTL3 is essential for postnatal development of brown adipose tissue and energy expenditure in mice

Abstract

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