Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

Hongnan Sun; Binbin Huang; Run Lin; Chao Yang; Wujiong Xia

doi:10.3762/bjoc.11.59

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

Hongnan Sun
, Binbin Huang
, Run Lin
, Chao Yang
, Wujiong Xia^*

^*Corresponding author for this work

School of Sciences

Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an S_N2-type ring opening followed by cyclization of the resulting haloalkoxy amine.

Original language	English
Pages (from-to)	524-529
Number of pages	6
Journal	Beilstein Journal of Organic Chemistry
Volume	11
DOIs	https://doi.org/10.3762/bjoc.11.59
State	Published - 22 Apr 2015

Keywords

Ammonium persulfate
Aziridine
Metal free
Morpholine

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title = "Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines",

abstract = "The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.",

keywords = "Ammonium persulfate, Aziridine, Metal free, Morpholine",

author = "Hongnan Sun and Binbin Huang and Run Lin and Chao Yang and Wujiong Xia",

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T1 - Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

AU - Sun, Hongnan

AU - Huang, Binbin

AU - Lin, Run

AU - Yang, Chao

AU - Xia, Wujiong

PY - 2015/4/22

Y1 - 2015/4/22

N2 - The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.

AB - The metal-free synthesis of 2-substituted and 2,3-disubstituted morpholines through a one-pot strategy is described. A simple and inexpensive ammonium persulfate salt enables the reaction of aziridines with halogenated alcohols to proceed via an SN2-type ring opening followed by cyclization of the resulting haloalkoxy amine.

KW - Ammonium persulfate

KW - Aziridine

KW - Metal free

KW - Morpholine

UR - https://www.scopus.com/pages/publications/84930639037

U2 - 10.3762/bjoc.11.59

DO - 10.3762/bjoc.11.59

M3 - 文章

AN - SCOPUS:84930639037

SN - 2195-951X

VL - 11

SP - 524

EP - 529

JO - Beilstein Journal of Organic Chemistry

JF - Beilstein Journal of Organic Chemistry

ER -

Metal-free one-pot synthesis of 2-substituted and 2,3-disubstituted morpholines from aziridines

Abstract

Keywords

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