Medical application of microbial biopolyesters polyhydroxyalkanoates

Qiong Wu; Yang Wang; Guo Qiang Chen

doi:10.1080/10731190802664429

Medical application of microbial biopolyesters polyhydroxyalkanoates

Qiong Wu
, Yang Wang
, Guo Qiang Chen^*

^*Corresponding author for this work

Ministry of Education of the People's Republic of China
Shantou University

Research output: Contribution to journal › Review article › peer-review

220 Scopus citations

Abstract

Polyhydroxyalkanoates (PHA) are a family of polyesters synthesized by microorganisms under unbalanced growth conditions. PHA including poly-3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV), poly-4-hydroxybutyrate (P4HB), copolymers of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and poly-3-hydroxyoctanoate (PHO) are now available in sufficient quantity for tissue engineering medical application studies due to their reasonable biocompatibility, adjustable mechanical properties, and controllable biodegradability. This paper reviews many achievements based on PHA for medical devices development, tissue repair, artificial organ construction, drug delivery, and nutritional/therapeutic uses. Combined with the recent FDA approval for P4HB clinical application, one can expect a good prospect for PHA application in the medical fields.

Original language	English
Pages (from-to)	1-12
Number of pages	12
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	37
Issue number	1
DOIs	https://doi.org/10.1080/10731190802664429
State	Published - Jan 2009
Externally published	Yes

Keywords

Biocompatibility
Biodegradability
Implant
Medical devices
PHB
Polyhydroxyalkanoates
Tissue engineering

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10.1080/10731190802664429

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title = "Medical application of microbial biopolyesters polyhydroxyalkanoates",

abstract = "Polyhydroxyalkanoates (PHA) are a family of polyesters synthesized by microorganisms under unbalanced growth conditions. PHA including poly-3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV), poly-4-hydroxybutyrate (P4HB), copolymers of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and poly-3-hydroxyoctanoate (PHO) are now available in sufficient quantity for tissue engineering medical application studies due to their reasonable biocompatibility, adjustable mechanical properties, and controllable biodegradability. This paper reviews many achievements based on PHA for medical devices development, tissue repair, artificial organ construction, drug delivery, and nutritional/therapeutic uses. Combined with the recent FDA approval for P4HB clinical application, one can expect a good prospect for PHA application in the medical fields.",

keywords = "Biocompatibility, Biodegradability, Implant, Medical devices, PHB, Polyhydroxyalkanoates, Tissue engineering",

author = "Qiong Wu and Yang Wang and Chen, \{Guo Qiang\}",

year = "2009",

month = jan,

doi = "10.1080/10731190802664429",

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volume = "37",

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AU - Wu, Qiong

AU - Wang, Yang

AU - Chen, Guo Qiang

PY - 2009/1

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N2 - Polyhydroxyalkanoates (PHA) are a family of polyesters synthesized by microorganisms under unbalanced growth conditions. PHA including poly-3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV), poly-4-hydroxybutyrate (P4HB), copolymers of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and poly-3-hydroxyoctanoate (PHO) are now available in sufficient quantity for tissue engineering medical application studies due to their reasonable biocompatibility, adjustable mechanical properties, and controllable biodegradability. This paper reviews many achievements based on PHA for medical devices development, tissue repair, artificial organ construction, drug delivery, and nutritional/therapeutic uses. Combined with the recent FDA approval for P4HB clinical application, one can expect a good prospect for PHA application in the medical fields.

AB - Polyhydroxyalkanoates (PHA) are a family of polyesters synthesized by microorganisms under unbalanced growth conditions. PHA including poly-3-hydroxybutyrate (PHB), copolymers of 3-hydroxybutyrate and 3-hydroxyvalerate (PHBV), poly-4-hydroxybutyrate (P4HB), copolymers of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and poly-3-hydroxyoctanoate (PHO) are now available in sufficient quantity for tissue engineering medical application studies due to their reasonable biocompatibility, adjustable mechanical properties, and controllable biodegradability. This paper reviews many achievements based on PHA for medical devices development, tissue repair, artificial organ construction, drug delivery, and nutritional/therapeutic uses. Combined with the recent FDA approval for P4HB clinical application, one can expect a good prospect for PHA application in the medical fields.

KW - Biocompatibility

KW - Biodegradability

KW - Implant

KW - Medical devices

KW - PHB

KW - Polyhydroxyalkanoates

KW - Tissue engineering

UR - https://www.scopus.com/pages/publications/61649126031

U2 - 10.1080/10731190802664429

DO - 10.1080/10731190802664429

M3 - 文献综述

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AN - SCOPUS:61649126031

SN - 1073-1199

VL - 37

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JO - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

JF - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

IS - 1

ER -

Medical application of microbial biopolyesters polyhydroxyalkanoates

Abstract

Keywords

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