Lncrna2target v2.0: A comprehensive database for target genes of lncrnas in human and mouse

Liang Cheng; Pingping Wang; Rui Tian; Song Wang; Qinghua Guo; Meng Luo; Wenyang Zhou; Guiyou Liu; Huijie Jiang; Qinghua Jiang

doi:10.1093/nar/gky1051

Lncrna2target v2.0: A comprehensive database for target genes of lncrnas in human and mouse

Liang Cheng
, Pingping Wang
, Rui Tian
, Song Wang
, Qinghua Guo
, Meng Luo
, Wenyang Zhou
, Guiyou Liu
, Huijie Jiang^*
, Qinghua Jiang

^*Corresponding author for this work

Harbin Medical University
School of Life Science and Technology, Harbin Institute of Technology
Shanghai University of Traditional Chinese Medicine
The Second Affiliated Hospital of Harbin Medical University

Research output: Contribution to journal › Article › peer-review

304 Scopus citations

Abstract

Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA-target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target.

Original language	English
Pages (from-to)	D140-D144
Journal	Nucleic Acids Research
Volume	47
Issue number	D1
DOIs	https://doi.org/10.1093/nar/gky1051
State	Published - 8 Jan 2019
Externally published	Yes

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10.1093/nar/gky1051

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title = "Lncrna2target v2.0: A comprehensive database for target genes of lncrnas in human and mouse",

abstract = "Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA-target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target.",

author = "Liang Cheng and Pingping Wang and Rui Tian and Song Wang and Qinghua Guo and Meng Luo and Wenyang Zhou and Guiyou Liu and Huijie Jiang and Qinghua Jiang",

note = "Publisher Copyright: {\textcopyright} The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research.",

year = "2019",

month = jan,

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doi = "10.1093/nar/gky1051",

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volume = "47",

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TY - JOUR

T1 - Lncrna2target v2.0

T2 - A comprehensive database for target genes of lncrnas in human and mouse

AU - Cheng, Liang

AU - Wang, Pingping

AU - Tian, Rui

AU - Wang, Song

AU - Guo, Qinghua

AU - Luo, Meng

AU - Zhou, Wenyang

AU - Liu, Guiyou

AU - Jiang, Huijie

AU - Jiang, Qinghua

PY - 2019/1/8

Y1 - 2019/1/8

N2 - Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA-target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target.

AB - Long non-coding RNAs (lncRNAs) play crucial roles in regulating gene expression, and a growing number of researchers have focused on the identification of target genes of lncRNAs. However, no online repository is available to collect the information on target genes regulated by lncRNAs. To make it convenient for researchers to know what genes are regulated by a lncRNA of interest, we developed a database named lncRNA2Target to provide a comprehensive resource of lncRNA target genes in 2015. To update the database this year, we retrieved all new lncRNA-target relationships from papers published from 1 August 2014 to 30 April 2018 and RNA-seq datasets before and after knockdown or overexpression of a specific lncRNA. LncRNA2Target database v2.0 provides a web interface through which its users can search for the targets of a particular lncRNA or for the lncRNAs that target a particular gene, and is freely accessible at http://123.59.132.21/lncrna2target.

UR - https://www.scopus.com/pages/publications/85059799076

U2 - 10.1093/nar/gky1051

DO - 10.1093/nar/gky1051

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AN - SCOPUS:85059799076

SN - 0305-1048

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SP - D140-D144

JO - Nucleic Acids Research

JF - Nucleic Acids Research

IS - D1

ER -

Lncrna2target v2.0: A comprehensive database for target genes of lncrnas in human and mouse

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