@inproceedings{dc39ef3f9c564b91a5018f65de455735,
title = "Liver mitochondrial DNA4977 deletion in alcoholic fatty liver disease and relation to ultrasound",
abstract = "Aim: To screen for the mitochondrial DNA 4977bp (mtDNA4977) deletion in the patients with alcoholic fatty liver disease (AFLD). Methods: Polymerase chain reaction (PCR) was carried out to detect mtDNA4977 deletion within 90 cases of AFLD plus 90 of normal controls. The ultrasound examination was conducted for the liver tissues of AFLD to compare liver function, blood fat level, body weight, and mtDNA4977 deletion among different ultrasound grades of AFLD. Results: With the aggravation of fatty change in live tissues of AFLD, deposition of both triglyceride (TG) and body mass index (BMI) in liver increased significantly (P<0.05). The mtDNA 4977 deletion was detected in 35.56\% (thirty-two cases) of the AFLD patients tested and occurred primarily ultrasound grade II or III, giving a significant difference compared to grade 0/I and normal live tissues (P <0.05). Conclusions: A small portion of the AFLD patients had the mtDNA 4977 deletion, and this mutation was detected only in high-grade fatty change of AFLD.",
keywords = "deletion mutation, liver disease, Mitochondria DNA",
author = "Liwei Zhuang and Tao Liang and Yili Fu",
year = "2011",
doi = "10.1109/ICCME.2011.5876717",
language = "英语",
isbn = "9781424493241",
series = "2011 IEEE/ICME International Conference on Complex Medical Engineering, CME 2011",
pages = "127--131",
booktitle = "2011 IEEE/ICME International Conference on Complex Medical Engineering, CME 2011",
note = "2011 5th IEEE/ICME International Conference on Complex Medical Engineering, CME 2011 ; Conference date: 22-05-2011 Through 25-05-2011",
}