Learning Lossless Compression for High Bit-Depth Medical Imaging

We propose a learned lossless image compression method for high bit-depth medical imaging (up to 16 bit-depths). Instead of compressing a high bit-depth medical image as a whole, we split it into two low bit-depth subimages, i.e., the most significant bytes (MSB) subimage and the least significant bytes (LSB) subimage, respectively. The MSB subimage depicts piece-wise smooth structure information that is relatively easy to compress. We thus use traditional lossless codecs for low complexity. The LSB subimage depicts the complementary texture information that is more challenging to compress. We design an autoregressive entropy model conditioned on the MSB subimage that models the probability distribution of the LSB subimage and effectively reduces the redundancy between the MSB and LSB subimages. We then encode the LSB subimage to bitstreams based on the learned entropy model. The compressed high bit-depth medical image is finally stored including the bitstreams of the MSB and LSB subimages. Experimental results demonstrate the state-of-the-art compression performance of the proposed method on high bit-depth medical images, compared with both existing traditional and learned lossless image codecs.