IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer

Yue Liu; Yang Hu; Yadong Wang

doi:10.1109/BIBM58861.2023.10385559

IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer

Yue Liu
, Yang Hu^*
, Yadong Wang^*

^*Corresponding author for this work

School of Computer Science and Technology, Harbin Institute of Technology

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

Both immune-related genes and tumor-infiltrating immune cells are sources of important prognostic information for patients with lymphatic invasive colon cancer. In this study, we first collected immune-related gene sets from immune-related databases, and immune cell types reflecting the tumor immune microenvironment obtained by deconvolution algorithm. Then, differentially expressed immune-related genes derived from weighted gene co-expression network analysis and differentially expressed immune cell types were used to construct a robust immune-related prognostic risk indicator (IRPRI) including 12 immune-related genes and 1 immune cell type after performing both univariate and multivariate Cox regression analyses, respectively. Afterward, we characterized the molecular and immune features between defined subgroups of IRPRI. We found significant differences in survival time and clinical features between high- and low-risk group samples. IRPRI serves as a potential prognostic indicator for colorectal cancer patients and may also contribute to evaluating the potential of immunotherapy for patients.

Original language	English
Title of host publication	Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023
Editors	Xingpeng Jiang, Haiying Wang, Reda Alhajj, Xiaohua Hu, Felix Engel, Mufti Mahmud, Nadia Pisanti, Xuefeng Cui, Hong Song
Publisher	Institute of Electrical and Electronics Engineers Inc.
Pages	255-259
Number of pages	5
ISBN (Electronic)	9798350337488
DOIs	https://doi.org/10.1109/BIBM58861.2023.10385559
State	Published - 2023
Externally published	Yes
Event	2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023 - Istanbul, Turkey Duration: 5 Dec 2023 → 8 Dec 2023

Publication series

Name	Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

Conference

Conference	2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023
Country/Territory	Turkey
City	Istanbul
Period	5/12/23 → 8/12/23

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

colon cancer
immune cells
immune-related genes
immune-related prognostic risk indicator (IRPRI)
prognostic indicator

Access to Document

10.1109/BIBM58861.2023.10385559

Cite this

Liu, Y., Hu, Y., & Wang, Y. (2023). IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer. In X. Jiang, H. Wang, R. Alhajj, X. Hu, F. Engel, M. Mahmud, N. Pisanti, X. Cui, & H. Song (Eds.), Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023 (pp. 255-259). (Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023). Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIBM58861.2023.10385559

Liu, Yue ; Hu, Yang ; Wang, Yadong. / IRPRI : An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer. Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023. editor / Xingpeng Jiang ; Haiying Wang ; Reda Alhajj ; Xiaohua Hu ; Felix Engel ; Mufti Mahmud ; Nadia Pisanti ; Xuefeng Cui ; Hong Song. Institute of Electrical and Electronics Engineers Inc., 2023. pp. 255-259 (Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023).

@inproceedings{e51b19445be3432696f5d8c8374bdd6a,

title = "IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer",

abstract = "Both immune-related genes and tumor-infiltrating immune cells are sources of important prognostic information for patients with lymphatic invasive colon cancer. In this study, we first collected immune-related gene sets from immune-related databases, and immune cell types reflecting the tumor immune microenvironment obtained by deconvolution algorithm. Then, differentially expressed immune-related genes derived from weighted gene co-expression network analysis and differentially expressed immune cell types were used to construct a robust immune-related prognostic risk indicator (IRPRI) including 12 immune-related genes and 1 immune cell type after performing both univariate and multivariate Cox regression analyses, respectively. Afterward, we characterized the molecular and immune features between defined subgroups of IRPRI. We found significant differences in survival time and clinical features between high- and low-risk group samples. IRPRI serves as a potential prognostic indicator for colorectal cancer patients and may also contribute to evaluating the potential of immunotherapy for patients.",

keywords = "colon cancer, immune cells, immune-related genes, immune-related prognostic risk indicator (IRPRI), prognostic indicator",

author = "Yue Liu and Yang Hu and Yadong Wang",

note = "Publisher Copyright: {\textcopyright} 2023 IEEE.; 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023 ; Conference date: 05-12-2023 Through 08-12-2023",

year = "2023",

doi = "10.1109/BIBM58861.2023.10385559",

language = "英语",

series = "Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "255--259",

editor = "Xingpeng Jiang and Haiying Wang and Reda Alhajj and Xiaohua Hu and Felix Engel and Mufti Mahmud and Nadia Pisanti and Xuefeng Cui and Hong Song",

booktitle = "Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023",

address = "美国",

}

Liu, Y, Hu, Y & Wang, Y 2023, IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer. in X Jiang, H Wang, R Alhajj, X Hu, F Engel, M Mahmud, N Pisanti, X Cui & H Song (eds), Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023. Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023, Institute of Electrical and Electronics Engineers Inc., pp. 255-259, 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023, Istanbul, Turkey, 5/12/23. https://doi.org/10.1109/BIBM58861.2023.10385559

IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer. / Liu, Yue; Hu, Yang ; Wang, Yadong.
Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023. ed. / Xingpeng Jiang; Haiying Wang; Reda Alhajj; Xiaohua Hu; Felix Engel; Mufti Mahmud; Nadia Pisanti; Xuefeng Cui; Hong Song. Institute of Electrical and Electronics Engineers Inc., 2023. p. 255-259 (Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - IRPRI

T2 - 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

AU - Liu, Yue

AU - Hu, Yang

AU - Wang, Yadong

PY - 2023

Y1 - 2023

N2 - Both immune-related genes and tumor-infiltrating immune cells are sources of important prognostic information for patients with lymphatic invasive colon cancer. In this study, we first collected immune-related gene sets from immune-related databases, and immune cell types reflecting the tumor immune microenvironment obtained by deconvolution algorithm. Then, differentially expressed immune-related genes derived from weighted gene co-expression network analysis and differentially expressed immune cell types were used to construct a robust immune-related prognostic risk indicator (IRPRI) including 12 immune-related genes and 1 immune cell type after performing both univariate and multivariate Cox regression analyses, respectively. Afterward, we characterized the molecular and immune features between defined subgroups of IRPRI. We found significant differences in survival time and clinical features between high- and low-risk group samples. IRPRI serves as a potential prognostic indicator for colorectal cancer patients and may also contribute to evaluating the potential of immunotherapy for patients.

AB - Both immune-related genes and tumor-infiltrating immune cells are sources of important prognostic information for patients with lymphatic invasive colon cancer. In this study, we first collected immune-related gene sets from immune-related databases, and immune cell types reflecting the tumor immune microenvironment obtained by deconvolution algorithm. Then, differentially expressed immune-related genes derived from weighted gene co-expression network analysis and differentially expressed immune cell types were used to construct a robust immune-related prognostic risk indicator (IRPRI) including 12 immune-related genes and 1 immune cell type after performing both univariate and multivariate Cox regression analyses, respectively. Afterward, we characterized the molecular and immune features between defined subgroups of IRPRI. We found significant differences in survival time and clinical features between high- and low-risk group samples. IRPRI serves as a potential prognostic indicator for colorectal cancer patients and may also contribute to evaluating the potential of immunotherapy for patients.

KW - colon cancer

KW - immune cells

KW - immune-related genes

KW - immune-related prognostic risk indicator (IRPRI)

KW - prognostic indicator

UR - https://www.scopus.com/pages/publications/85184879700

U2 - 10.1109/BIBM58861.2023.10385559

DO - 10.1109/BIBM58861.2023.10385559

M3 - 会议稿件

AN - SCOPUS:85184879700

T3 - Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

SP - 255

EP - 259

BT - Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023

A2 - Jiang, Xingpeng

A2 - Wang, Haiying

A2 - Alhajj, Reda

A2 - Hu, Xiaohua

A2 - Engel, Felix

A2 - Mahmud, Mufti

A2 - Pisanti, Nadia

A2 - Cui, Xuefeng

A2 - Song, Hong

PB - Institute of Electrical and Electronics Engineers Inc.

Y2 - 5 December 2023 through 8 December 2023

ER -

Liu Y, Hu Y , Wang Y. IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer. In Jiang X, Wang H, Alhajj R, Hu X, Engel F, Mahmud M, Pisanti N, Cui X, Song H, editors, Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023. Institute of Electrical and Electronics Engineers Inc. 2023. p. 255-259. (Proceedings - 2023 2023 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2023). doi: 10.1109/BIBM58861.2023.10385559

IRPRI: An immune-related prognostic risk indicator for patients with lymphatic invasive colon cancer

Abstract

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UN SDGs

Keywords

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