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Investigation of the interference of carbon nanomaterials with SYBR Green I-based real-time PCR

  • School of Marine Science and Technology, Harbin Institute of Technology Weihai
  • Jilin University

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Some carbon nanomaterials have been proved to be able to improve the PCR amplification efficiency. If used in quantitative real-time PCR (qPCR), these nanomaterials must be tested whether fluorescence processing is interfered after they are added in the PCR system. In this study, 76 different carbon nanomaterials were tested in SYBR Green I-based qPCR, and the results demonstrated that about half carbon nanomaterials tested in this study could alter the PCR amplification profile probably due to the fluorescence quenching. Surprisingly, lower concentrations of nanomaterials led to more slight interference with the melting temperature.

Original languageEnglish
Title of host publicationCurrent Trends in the Development of Industry
Pages550-555
Number of pages6
DOIs
StatePublished - 2013
Externally publishedYes
Event3rd International Conference on Chemical Engineering and Advanced Materials, CEAM 2013 - Guangzhou, China
Duration: 6 Jul 20137 Jul 2013

Publication series

NameAdvanced Materials Research
Volume785-786
ISSN (Print)1022-6680

Conference

Conference3rd International Conference on Chemical Engineering and Advanced Materials, CEAM 2013
Country/TerritoryChina
CityGuangzhou
Period6/07/137/07/13

Keywords

  • Carbon nanomaterials
  • Fluorescence quenching
  • Melting temperature
  • Real-time PCR

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