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Intracerebral Haemorrhage Growth Prediction Based on Displacement Vector Field and Clinical Metadata

  • Ting Xiao*
  • , Han Zheng
  • , Xiaoning Wang
  • , Xinghan Chen
  • , Jianbo Chang
  • , Jianhua Yao
  • , Hong Shang
  • , Peng Liu
  • *Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Intracerebral hemorrhage (ICH) is the deadliest type of stroke. Early prediction of stroke lesion growth is crucial in assisting physicians towards better stroke assessments. Existing stroke lesion prediction methods are mainly for ischemic stroke. In ICH, most methods only focus on whether the hematoma will expand but not how it will develop. This paper explored a new, unknown topic of predicting ICH growth at the image-level based on the baseline non-contrast computerized tomography (NCCT) image and its hematoma mask. We propose a novel end-to-end prediction framework based on the displacement vector fields (DVF) with the following advantages. 1) It can simultaneously predict CT image and hematoma mask at follow-up, providing more clinical assessment references and surgery indication. 2) The DVF regularization enforces a smooth spatial deformation, limiting the degree of the stroke lesion changes and lowering the requirement of large data. 3) A multi-modal fusion module learns high-level associations between global clinical features and spatial image features. Experiments on a multi-center dataset demonstrate improved performance compared to several strong baselines. Detailed ablation experiments are conducted to highlight the contributions of various components.

Original languageEnglish
Title of host publicationMedical Image Computing and Computer Assisted Intervention – MICCAI 2021 - 24th International Conference, Proceedings
EditorsMarleen de Bruijne, Philippe C. Cattin, Stéphane Cotin, Nicolas Padoy, Stefanie Speidel, Yefeng Zheng, Caroline Essert
PublisherSpringer Science and Business Media Deutschland GmbH
Pages741-751
Number of pages11
ISBN (Print)9783030872397
DOIs
StatePublished - 2021
Event24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021 - Virtual, Online
Duration: 27 Sep 20211 Oct 2021

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume12905 LNCS
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference24th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2021
CityVirtual, Online
Period27/09/211/10/21

Keywords

  • Clinical metadata
  • DNN
  • Displacement vector field
  • Hemorrhage growth prediction
  • Multi-modal fusion
  • Stroke

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