TY - JOUR
T1 - Interaction-aware dexterous robot for minimally invasive transcanal inner ear interventions
AU - Li, Haiming
AU - Gao, Peiyuan
AU - Tan, Haoyue
AU - Li, Haotian
AU - Zhu, Haifeng
AU - Jiang, Mengyuan
AU - Ni, Yuting
AU - He, Yandi
AU - Huang, Junhong
AU - Zhu, Yue
AU - Yang, Jiahui
AU - Wang, Chunbo
AU - Liu, Bin
AU - Du, Fuxin
AU - Zhu, Yanhe
AU - Dong, Huijuan
AU - Zhang, He
AU - Zhang, Tianxue
AU - Jia, Huan
AU - Wu, Hao
AU - Zhao, Jie
N1 - Publisher Copyright:
© The Author(s) 2026.
PY - 2026/12
Y1 - 2026/12
N2 - Intracochlear theranostics, particularly targeted drug delivery and microsampling, offers a promising solution to inner ear diseases. However, specialized medical devices remain limited by a fundamental design challenge imposed by anatomical constraints: balancing miniaturization, dexterity, and perceptive functionality. Here, we present a low–aspect-ratio, dual-segment continuum robot that integrates catheter, endoscopic and instrumental functions. Driven by antagonistic cables, the robot uses a transition-free backbone composed of saddle-shaped joints to achieve a minimum bending radius of 1.9 mm. Dual-segment motion decoupling yields programmable C-/S-shaped configurations, facilitating anatomical navigation. The microneedle, embedded in the central channel, serves as an end-effector with positioning accuracy of 17.9 ± 4.1 μm. Fiber Bragg grating sensors, mounted on the needle, measure axial force to estimate tool-tissue interaction. Validation is performed on cadavers and in vivo animals, demonstrating the feasibility of a transcanal, atraumatic robotic paradigm. Thus, this system provides a practical and accessible approach for early diagnosis and treatment, helping extend precision medicine to underserved areas.
AB - Intracochlear theranostics, particularly targeted drug delivery and microsampling, offers a promising solution to inner ear diseases. However, specialized medical devices remain limited by a fundamental design challenge imposed by anatomical constraints: balancing miniaturization, dexterity, and perceptive functionality. Here, we present a low–aspect-ratio, dual-segment continuum robot that integrates catheter, endoscopic and instrumental functions. Driven by antagonistic cables, the robot uses a transition-free backbone composed of saddle-shaped joints to achieve a minimum bending radius of 1.9 mm. Dual-segment motion decoupling yields programmable C-/S-shaped configurations, facilitating anatomical navigation. The microneedle, embedded in the central channel, serves as an end-effector with positioning accuracy of 17.9 ± 4.1 μm. Fiber Bragg grating sensors, mounted on the needle, measure axial force to estimate tool-tissue interaction. Validation is performed on cadavers and in vivo animals, demonstrating the feasibility of a transcanal, atraumatic robotic paradigm. Thus, this system provides a practical and accessible approach for early diagnosis and treatment, helping extend precision medicine to underserved areas.
UR - https://www.scopus.com/pages/publications/105043428552
U2 - 10.1038/s41467-026-72398-5
DO - 10.1038/s41467-026-72398-5
M3 - 文章
C2 - 42031753
AN - SCOPUS:105043428552
SN - 2041-1723
VL - 17
JO - Nature Communications
JF - Nature Communications
IS - 1
M1 - 5658
ER -