Integrated porous polyetheretherketone/hydroxyapatite scaffolds: design, manufacturing and performance evaluation

Shuai Li; Gao Li; Xu Lian; Jiqiang Hu; Menglei Li; Bing Wang; Yajun Zou; Zhengong Zhou

doi:10.1016/j.compositesa.2023.107656

Integrated porous polyetheretherketone/hydroxyapatite scaffolds: design, manufacturing and performance evaluation

Shuai Li
, Gao Li
, Xu Lian
, Jiqiang Hu
, Menglei Li
, Bing Wang^*
, Yajun Zou
, Zhengong Zhou

^*Corresponding author for this work

School of Astronautics

Harbin Institute of Technology
Aerospace System Engineering Shanghai

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

Polyetheretherketone (PEEK) is widely applied in bone grafting benefiting from its matched elastic modulus to cortical bone and excellent biocompatibility, but suffers from bioinertness. From this issue, integrated porous polyetheretherketone/hydroxyapatite scaffold (PEEK/HA-S) was designed and fabricated via aluminum wire 3D braiding-powder filling-heat press-alkaline solution corrosion method, and characterized by mechanical tests. The PEEK/HA-S possessed average pore diameter of 604.8 μm, porosity of 41.69 %, pore interconnectivity of 100 % and specific surface area of 3.70 mm⁻¹. Numerical simulations and theoretical model were carried out to further illustrate the mechanical responses and failure mechanism of PEEK/HA-S. A close agreement between numerical, theoretical and experimental results was observed. The PEEK/HA-S exhibited superior mechanical properties than that prepared by traditional technology due to its integrated structures, and its mechanical properties lied in those of cortical and cancellous bone, which was benefit to mitigate stress shielding. Overall, integrated PEEK/HA-S is highly competitive for bone restorations.

Original language	English
Article number	107656
Journal	Composites Part A: Applied Science and Manufacturing
Volume	173
DOIs	https://doi.org/10.1016/j.compositesa.2023.107656
State	Published - Oct 2023

Keywords

A. Polymer-matrix composites (PMCs)
B. Mechanical properties
C. Finite element analysis (FEA)
E. Compression moulding

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10.1016/j.compositesa.2023.107656

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@article{742142646c36412a8911afaa82e052ae,

title = "Integrated porous polyetheretherketone/hydroxyapatite scaffolds: design, manufacturing and performance evaluation",

abstract = "Polyetheretherketone (PEEK) is widely applied in bone grafting benefiting from its matched elastic modulus to cortical bone and excellent biocompatibility, but suffers from bioinertness. From this issue, integrated porous polyetheretherketone/hydroxyapatite scaffold (PEEK/HA-S) was designed and fabricated via aluminum wire 3D braiding-powder filling-heat press-alkaline solution corrosion method, and characterized by mechanical tests. The PEEK/HA-S possessed average pore diameter of 604.8 μm, porosity of 41.69 \%, pore interconnectivity of 100 \% and specific surface area of 3.70 mm−1. Numerical simulations and theoretical model were carried out to further illustrate the mechanical responses and failure mechanism of PEEK/HA-S. A close agreement between numerical, theoretical and experimental results was observed. The PEEK/HA-S exhibited superior mechanical properties than that prepared by traditional technology due to its integrated structures, and its mechanical properties lied in those of cortical and cancellous bone, which was benefit to mitigate stress shielding. Overall, integrated PEEK/HA-S is highly competitive for bone restorations.",

keywords = "A. Polymer-matrix composites (PMCs), B. Mechanical properties, C. Finite element analysis (FEA), E. Compression moulding",

author = "Shuai Li and Gao Li and Xu Lian and Jiqiang Hu and Menglei Li and Bing Wang and Yajun Zou and Zhengong Zhou",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = oct,

doi = "10.1016/j.compositesa.2023.107656",

language = "英语",

volume = "173",

journal = "Composites Part A: Applied Science and Manufacturing",

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TY - JOUR

T1 - Integrated porous polyetheretherketone/hydroxyapatite scaffolds

T2 - design, manufacturing and performance evaluation

AU - Li, Shuai

AU - Li, Gao

AU - Lian, Xu

AU - Hu, Jiqiang

AU - Li, Menglei

AU - Wang, Bing

AU - Zou, Yajun

AU - Zhou, Zhengong

PY - 2023/10

Y1 - 2023/10

N2 - Polyetheretherketone (PEEK) is widely applied in bone grafting benefiting from its matched elastic modulus to cortical bone and excellent biocompatibility, but suffers from bioinertness. From this issue, integrated porous polyetheretherketone/hydroxyapatite scaffold (PEEK/HA-S) was designed and fabricated via aluminum wire 3D braiding-powder filling-heat press-alkaline solution corrosion method, and characterized by mechanical tests. The PEEK/HA-S possessed average pore diameter of 604.8 μm, porosity of 41.69 %, pore interconnectivity of 100 % and specific surface area of 3.70 mm−1. Numerical simulations and theoretical model were carried out to further illustrate the mechanical responses and failure mechanism of PEEK/HA-S. A close agreement between numerical, theoretical and experimental results was observed. The PEEK/HA-S exhibited superior mechanical properties than that prepared by traditional technology due to its integrated structures, and its mechanical properties lied in those of cortical and cancellous bone, which was benefit to mitigate stress shielding. Overall, integrated PEEK/HA-S is highly competitive for bone restorations.

AB - Polyetheretherketone (PEEK) is widely applied in bone grafting benefiting from its matched elastic modulus to cortical bone and excellent biocompatibility, but suffers from bioinertness. From this issue, integrated porous polyetheretherketone/hydroxyapatite scaffold (PEEK/HA-S) was designed and fabricated via aluminum wire 3D braiding-powder filling-heat press-alkaline solution corrosion method, and characterized by mechanical tests. The PEEK/HA-S possessed average pore diameter of 604.8 μm, porosity of 41.69 %, pore interconnectivity of 100 % and specific surface area of 3.70 mm−1. Numerical simulations and theoretical model were carried out to further illustrate the mechanical responses and failure mechanism of PEEK/HA-S. A close agreement between numerical, theoretical and experimental results was observed. The PEEK/HA-S exhibited superior mechanical properties than that prepared by traditional technology due to its integrated structures, and its mechanical properties lied in those of cortical and cancellous bone, which was benefit to mitigate stress shielding. Overall, integrated PEEK/HA-S is highly competitive for bone restorations.

KW - A. Polymer-matrix composites (PMCs)

KW - B. Mechanical properties

KW - C. Finite element analysis (FEA)

KW - E. Compression moulding

UR - https://www.scopus.com/pages/publications/85161968130

U2 - 10.1016/j.compositesa.2023.107656

DO - 10.1016/j.compositesa.2023.107656

M3 - 文章

AN - SCOPUS:85161968130

SN - 1359-835X

VL - 173

JO - Composites Part A: Applied Science and Manufacturing

JF - Composites Part A: Applied Science and Manufacturing

M1 - 107656

ER -

Integrated porous polyetheretherketone/hydroxyapatite scaffolds: design, manufacturing and performance evaluation

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