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Integrated optofluidic label-free biosensors using a silicon-nitride-based coupled-resonator optical waveguide

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Abstract

In this paper, we report our recent progress in silicon-nitride-based optofluidic label-free biosensors using a surfacefunctionalized coupled-resonator optical waveguide (CROW) in the visible wavelengths. The working principle is based on far-field imaging of the CROW mode-field intensity distributions at a fixed probe wavelength. The imaged pattern variation reflects real-time analyte-binding information on the CROW surfaces. Our surface-functionalized 16- microring CROW reveals six eigenstates with distinctive mode-field intensity distributions. Our proof-of-concept sensing experiment at an arbitrarily chosen probe wavelength within the CROW transmission band shows a detection of streptavidin concentration down to 40 ng/ml.

Original languageEnglish
Title of host publicationIntegrated Optics
Subtitle of host publicationDevices, Materials, and Technologies XX
EditorsGualtiero Nunzi Conti, Jean-Emmanuel Broquin
PublisherSPIE
ISBN (Electronic)9781628419856
DOIs
StatePublished - 2016
Externally publishedYes
EventIntegrated Optics: Devices, Materials, and Technologies XX - San Francisco, United States
Duration: 15 Feb 201617 Feb 2016

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9750
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

ConferenceIntegrated Optics: Devices, Materials, and Technologies XX
Country/TerritoryUnited States
CitySan Francisco
Period15/02/1617/02/16

Keywords

  • CMOS-compatible
  • Label-free biosensors
  • coupled-resonator optical waveguide (CROW)
  • elastic light scattering
  • integrated optofluidics
  • microring resonators
  • silicon nitride
  • visible wavelengths

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