Influence of silicon concentration on the haemocompatibility of amorphous carbon

Soon Eng Ong; Sam Zhang; Hejun Du; Hui Chin Too; Kyaw Naing Aung

doi:10.1016/j.biomaterials.2007.05.031

Influence of silicon concentration on the haemocompatibility of amorphous carbon

Soon Eng Ong
, Sam Zhang^*
, Hejun Du
, Hui Chin Too
, Kyaw Naing Aung

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Amorphous carbon (a-C) has good blood compatibility and has been proposed as a coating material for blood contacting devices such as heart pumps and stents. In this study, unhydrogenated a-C films with different silicon concentrations were synthesized by magnetron sputtering, and the corresponding evolution of the surface energy and compatibility with blood were analysed. The incorporation of silicon not only decreased the sp²-hybridized carbon bonding configurations, but the static evaluation of the films incubated in human platelet-rich plasma also showed a decrease in platelet adhesion. Bonding structure and surface energy were determined to be factors contributing to the improved haemocompatibility.

Original language	English
Pages (from-to)	4033-4038
Number of pages	6
Journal	Biomaterials
Volume	28
Issue number	28
DOIs	https://doi.org/10.1016/j.biomaterials.2007.05.031
State	Published - Oct 2007
Externally published	Yes

Keywords

Amorphous carbon
Bonding structure
Haemocompatibility
Human platelet adhesion
Silicon-incorporation
Surface energy

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10.1016/j.biomaterials.2007.05.031

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title = "Influence of silicon concentration on the haemocompatibility of amorphous carbon",

abstract = "Amorphous carbon (a-C) has good blood compatibility and has been proposed as a coating material for blood contacting devices such as heart pumps and stents. In this study, unhydrogenated a-C films with different silicon concentrations were synthesized by magnetron sputtering, and the corresponding evolution of the surface energy and compatibility with blood were analysed. The incorporation of silicon not only decreased the sp2-hybridized carbon bonding configurations, but the static evaluation of the films incubated in human platelet-rich plasma also showed a decrease in platelet adhesion. Bonding structure and surface energy were determined to be factors contributing to the improved haemocompatibility.",

keywords = "Amorphous carbon, Bonding structure, Haemocompatibility, Human platelet adhesion, Silicon-incorporation, Surface energy",

author = "Ong, \{Soon Eng\} and Sam Zhang and Hejun Du and Too, \{Hui Chin\} and Aung, \{Kyaw Naing\}",

year = "2007",

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doi = "10.1016/j.biomaterials.2007.05.031",

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T1 - Influence of silicon concentration on the haemocompatibility of amorphous carbon

AU - Ong, Soon Eng

AU - Zhang, Sam

AU - Du, Hejun

AU - Too, Hui Chin

AU - Aung, Kyaw Naing

PY - 2007/10

Y1 - 2007/10

N2 - Amorphous carbon (a-C) has good blood compatibility and has been proposed as a coating material for blood contacting devices such as heart pumps and stents. In this study, unhydrogenated a-C films with different silicon concentrations were synthesized by magnetron sputtering, and the corresponding evolution of the surface energy and compatibility with blood were analysed. The incorporation of silicon not only decreased the sp2-hybridized carbon bonding configurations, but the static evaluation of the films incubated in human platelet-rich plasma also showed a decrease in platelet adhesion. Bonding structure and surface energy were determined to be factors contributing to the improved haemocompatibility.

AB - Amorphous carbon (a-C) has good blood compatibility and has been proposed as a coating material for blood contacting devices such as heart pumps and stents. In this study, unhydrogenated a-C films with different silicon concentrations were synthesized by magnetron sputtering, and the corresponding evolution of the surface energy and compatibility with blood were analysed. The incorporation of silicon not only decreased the sp2-hybridized carbon bonding configurations, but the static evaluation of the films incubated in human platelet-rich plasma also showed a decrease in platelet adhesion. Bonding structure and surface energy were determined to be factors contributing to the improved haemocompatibility.

KW - Amorphous carbon

KW - Bonding structure

KW - Haemocompatibility

KW - Human platelet adhesion

KW - Silicon-incorporation

KW - Surface energy

UR - https://www.scopus.com/pages/publications/34447282271

U2 - 10.1016/j.biomaterials.2007.05.031

DO - 10.1016/j.biomaterials.2007.05.031

M3 - 文章

C2 - 17576006

AN - SCOPUS:34447282271

SN - 0142-9612

VL - 28

SP - 4033

EP - 4038

JO - Biomaterials

JF - Biomaterials

IS - 28

ER -

Influence of silicon concentration on the haemocompatibility of amorphous carbon

Abstract

Keywords

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