InCl3-catalyzed propargylation of indoles and phenols with propargylic acetates: Application to the syntheses of benzofurans and naphthofurans

Zhe Liu; Li Liu; Zahid Shafiq; Yan Chao Wu; Dong Wang; Yong Jun Chen

doi:10.1055/s-2007-983735

InCl₃-catalyzed propargylation of indoles and phenols with propargylic acetates: Application to the syntheses of benzofurans and naphthofurans

Zhe Liu
, Li Liu^*
, Zahid Shafiq
, Yan Chao Wu
, Dong Wang
, Yong Jun Chen

^*Corresponding author for this work

CAS - Institute of Chemistry
University of Chinese Academy of Sciences

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

InCl₃-catalyzed propargylation of indoles and phenols was developed. A strategy combining propargylation with intramolecular cyclization was used to easily prepare 2-benzyl-3-arylbenzofurans and -naphthofurans, which are important pharmaceutical intermediates.

Original language	English
Pages (from-to)	1961-1969
Number of pages	9
Journal	Synthesis (Germany)
Issue number	13
DOIs	https://doi.org/10.1055/s-2007-983735
State	Published - 3 Jul 2007
Externally published	Yes

Keywords

Benzofuran
Cyclization
Friedel-Crafts alkylation
InCl
Propargylation

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10.1055/s-2007-983735

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title = "InCl3-catalyzed propargylation of indoles and phenols with propargylic acetates: Application to the syntheses of benzofurans and naphthofurans",

abstract = "InCl3-catalyzed propargylation of indoles and phenols was developed. A strategy combining propargylation with intramolecular cyclization was used to easily prepare 2-benzyl-3-arylbenzofurans and -naphthofurans, which are important pharmaceutical intermediates.",

keywords = "Benzofuran, Cyclization, Friedel-Crafts alkylation, InCl, Propargylation",

author = "Zhe Liu and Li Liu and Zahid Shafiq and Wu, \{Yan Chao\} and Dong Wang and Chen, \{Yong Jun\}",

year = "2007",

month = jul,

day = "3",

doi = "10.1055/s-2007-983735",

language = "英语",

pages = "1961--1969",

journal = "Synthesis (Germany)",

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publisher = "Georg Thieme Verlag",

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TY - JOUR

T1 - InCl3-catalyzed propargylation of indoles and phenols with propargylic acetates

T2 - Application to the syntheses of benzofurans and naphthofurans

AU - Liu, Zhe

AU - Liu, Li

AU - Shafiq, Zahid

AU - Wu, Yan Chao

AU - Wang, Dong

AU - Chen, Yong Jun

PY - 2007/7/3

Y1 - 2007/7/3

N2 - InCl3-catalyzed propargylation of indoles and phenols was developed. A strategy combining propargylation with intramolecular cyclization was used to easily prepare 2-benzyl-3-arylbenzofurans and -naphthofurans, which are important pharmaceutical intermediates.

AB - InCl3-catalyzed propargylation of indoles and phenols was developed. A strategy combining propargylation with intramolecular cyclization was used to easily prepare 2-benzyl-3-arylbenzofurans and -naphthofurans, which are important pharmaceutical intermediates.

KW - Benzofuran

KW - Cyclization

KW - Friedel-Crafts alkylation

KW - InCl

KW - Propargylation

UR - https://www.scopus.com/pages/publications/34447509611

U2 - 10.1055/s-2007-983735

DO - 10.1055/s-2007-983735

M3 - 文章

AN - SCOPUS:34447509611

SN - 0039-7881

SP - 1961

EP - 1969

JO - Synthesis (Germany)

JF - Synthesis (Germany)

IS - 13

ER -

InCl₃-catalyzed propargylation of indoles and phenols with propargylic acetates: Application to the syntheses of benzofurans and naphthofurans

Abstract

Keywords

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