In-vitro evaluation of Mg-4.0Zn-0.2Ca alloy for biomedical application

Yu Sun; Min Xiu Kong; Xiao Hui Jiao

doi:10.1016/S1003-6326(11)61587-2

In-vitro evaluation of Mg-4.0Zn-0.2Ca alloy for biomedical application

Yu Sun
, Min Xiu Kong
, Xiao Hui Jiao^*

^*Corresponding author for this work

School of Mechatronics Engineering

Harbin Medical University

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.

Original language	English
Pages (from-to)	s252-s257
Journal	Transactions of Nonferrous Metals Society of China (English Edition)
Volume	21
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/S1003-6326(11)61587-2
State	Published - Aug 2011

Keywords

biocompatibility
biodegradation
cytotoxicity
magnesium alloy

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10.1016/S1003-6326(11)61587-2

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abstract = "The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.",

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AU - Sun, Yu

AU - Kong, Min Xiu

AU - Jiao, Xiao Hui

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Y1 - 2011/8

N2 - The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.

AB - The in-vitro degradation and in-vitro cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy were investigated. The in-vitro corrosion tests indicate that Zn and Ca elements can dramatically increase the corrosion potential of the as-extruded Mg-4.0Zn-0.2Ca alloy in the simulated body fluid and reduce the degradation rate. The cytotoxicity of the as-extruded Mg-4.0Zn-0.2Ca alloy examined by MTT tests on L929 cells suggest that the alloy has eligible toxicity for implant applications.

KW - biocompatibility

KW - biodegradation

KW - cytotoxicity

KW - magnesium alloy

UR - https://www.scopus.com/pages/publications/82455219193

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M3 - 文章

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SN - 1003-6326

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JO - Transactions of Nonferrous Metals Society of China (English Edition)

JF - Transactions of Nonferrous Metals Society of China (English Edition)

IS - SUPPL. 2

ER -

In-vitro evaluation of Mg-4.0Zn-0.2Ca alloy for biomedical application

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Keywords

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