Abstract
In this paper, the in-vitro cytotoxicity and the in-vivo compatibility of Mg-4.0Zn-0.2Ca alloy are studied. The cytotoxicity of Mg-4.0Zn-0.2Ca alloy is examined by MTT method on osteoblast cells. The in-vivo behavior of Mg-4.0Zn-0.2Ca alloy is investigated on rabbits. It has been found that Mg-4.0Zn-0.2Ca alloy extract has no cytotoxicity on osteoblast cells. Three months after in-vivo experiment, about 35-38% magnesium alloy implant has been degraded and a degradation layer which is composed of Ca, P, O and Mg has been formed on the magnesium alloy implants. Histological analysis showed that new bone is observed around magnesium implant without inflammation reaction. In-vitro and in-vivo test indicated that the Mg-4.0Zn-0.2Ca alloy has good biocompatibility.
| Original language | English |
|---|---|
| Pages (from-to) | 665-669 |
| Number of pages | 5 |
| Journal | Materials Science and Engineering C |
| Volume | 32 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1 May 2012 |
| Externally published | Yes |
Keywords
- Biodegradation
- Cytotoxicity
- Implant
- Magnesium
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