Improved biocompatibility of thrombo-resistant iron-polysaccharides multilayer coatings on Nitinols

Yan Ma; Meng Liu; Xiuli Yue; Zhengbao Zha; Zhifei Dai

doi:10.1016/j.ijbiomac.2009.10.017

Improved biocompatibility of thrombo-resistant iron-polysaccharides multilayer coatings on Nitinols

Yan Ma
, Meng Liu
, Xiuli Yue
, Zhengbao Zha
, Zhifei Dai^*

^*Corresponding author for this work

School of Environment

Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Biocompatibility of two multilayer coatings of (Fe³⁺/Hep)₁₀ and (Fe³⁺/DS/Fe³⁺/Hep)₅ was comparatively analyzed with respect to protein adsorption, leukocyte adhesion and cell-material interaction. Both of them showed significantly high albumin-to-fibrinogen adsorption ratio, suggesting good biocompatibility. Furthermore, the (Fe³⁺/DS/Fe³⁺/Hep)₅ coating was found to exhibit the lowest non-specific protein adsorption due to the incorporation of dextran sulfate. Compared with uncoated Nitinol surfaces, iron-polysaccharide multilayer coating presented no deformation of leukocytes, indicating no signs of inflammatory reactions. Cell growth, cell adhesion and cell metabolic activity were all in good condition, verifying both (Fe³⁺/Hep)₁₀ and (Fe³⁺/DS/Fe³⁺/Hep)₅ coatings had good cytocompatibility. Therefore, iron-polysaccharides multilayer coatings had greatly improved the biocompatibility of Nitinols.

Original language	English
Pages (from-to)	109-114
Number of pages	6
Journal	International Journal of Biological Macromolecules
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.ijbiomac.2009.10.017
State	Published - 1 Jan 2010

Keywords

Biocompatibility
Hemocompatible coating
Protein adsorption

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10.1016/j.ijbiomac.2009.10.017

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title = "Improved biocompatibility of thrombo-resistant iron-polysaccharides multilayer coatings on Nitinols",

abstract = "Biocompatibility of two multilayer coatings of (Fe3+/Hep)10 and (Fe3+/DS/Fe3+/Hep)5 was comparatively analyzed with respect to protein adsorption, leukocyte adhesion and cell-material interaction. Both of them showed significantly high albumin-to-fibrinogen adsorption ratio, suggesting good biocompatibility. Furthermore, the (Fe3+/DS/Fe3+/Hep)5 coating was found to exhibit the lowest non-specific protein adsorption due to the incorporation of dextran sulfate. Compared with uncoated Nitinol surfaces, iron-polysaccharide multilayer coating presented no deformation of leukocytes, indicating no signs of inflammatory reactions. Cell growth, cell adhesion and cell metabolic activity were all in good condition, verifying both (Fe3+/Hep)10 and (Fe3+/DS/Fe3+/Hep)5 coatings had good cytocompatibility. Therefore, iron-polysaccharides multilayer coatings had greatly improved the biocompatibility of Nitinols.",

keywords = "Biocompatibility, Hemocompatible coating, Protein adsorption",

author = "Yan Ma and Meng Liu and Xiuli Yue and Zhengbao Zha and Zhifei Dai",

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doi = "10.1016/j.ijbiomac.2009.10.017",

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TY - JOUR

T1 - Improved biocompatibility of thrombo-resistant iron-polysaccharides multilayer coatings on Nitinols

AU - Ma, Yan

AU - Liu, Meng

AU - Yue, Xiuli

AU - Zha, Zhengbao

AU - Dai, Zhifei

PY - 2010/1/1

Y1 - 2010/1/1

N2 - Biocompatibility of two multilayer coatings of (Fe3+/Hep)10 and (Fe3+/DS/Fe3+/Hep)5 was comparatively analyzed with respect to protein adsorption, leukocyte adhesion and cell-material interaction. Both of them showed significantly high albumin-to-fibrinogen adsorption ratio, suggesting good biocompatibility. Furthermore, the (Fe3+/DS/Fe3+/Hep)5 coating was found to exhibit the lowest non-specific protein adsorption due to the incorporation of dextran sulfate. Compared with uncoated Nitinol surfaces, iron-polysaccharide multilayer coating presented no deformation of leukocytes, indicating no signs of inflammatory reactions. Cell growth, cell adhesion and cell metabolic activity were all in good condition, verifying both (Fe3+/Hep)10 and (Fe3+/DS/Fe3+/Hep)5 coatings had good cytocompatibility. Therefore, iron-polysaccharides multilayer coatings had greatly improved the biocompatibility of Nitinols.

AB - Biocompatibility of two multilayer coatings of (Fe3+/Hep)10 and (Fe3+/DS/Fe3+/Hep)5 was comparatively analyzed with respect to protein adsorption, leukocyte adhesion and cell-material interaction. Both of them showed significantly high albumin-to-fibrinogen adsorption ratio, suggesting good biocompatibility. Furthermore, the (Fe3+/DS/Fe3+/Hep)5 coating was found to exhibit the lowest non-specific protein adsorption due to the incorporation of dextran sulfate. Compared with uncoated Nitinol surfaces, iron-polysaccharide multilayer coating presented no deformation of leukocytes, indicating no signs of inflammatory reactions. Cell growth, cell adhesion and cell metabolic activity were all in good condition, verifying both (Fe3+/Hep)10 and (Fe3+/DS/Fe3+/Hep)5 coatings had good cytocompatibility. Therefore, iron-polysaccharides multilayer coatings had greatly improved the biocompatibility of Nitinols.

KW - Biocompatibility

KW - Hemocompatible coating

KW - Protein adsorption

UR - https://www.scopus.com/pages/publications/71849096924

U2 - 10.1016/j.ijbiomac.2009.10.017

DO - 10.1016/j.ijbiomac.2009.10.017

M3 - 文章

C2 - 19896498

AN - SCOPUS:71849096924

SN - 0141-8130

VL - 46

SP - 109

EP - 114

JO - International Journal of Biological Macromolecules

JF - International Journal of Biological Macromolecules

IS - 1

ER -

Improved biocompatibility of thrombo-resistant iron-polysaccharides multilayer coatings on Nitinols

Abstract

Keywords

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