Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

Zeyu Li; Jiatong Ni; Liping Liu; Liyuan Gu; Zhiguang Wu; Tianlong Li; Krasnyuk Ivan Ivanovich; Wancheng Zhao; Tiedong Sun; Ting Wang

doi:10.1021/acsami.1c05079

Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

Zeyu Li
, Jiatong Ni
, Liping Liu
, Liyuan Gu
, Zhiguang Wu
, Tianlong Li
, Krasnyuk Ivan Ivanovich
, Wancheng Zhao
, Tiedong Sun^*
, Ting Wang^*

^*Corresponding author for this work

Northeast Forestry University
Harbin First Specialist Hospital
Henan Agricultural University
Sechenov First Moscow State Medical University

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.

Original language	English
Pages (from-to)	29340-29348
Number of pages	9
Journal	ACS Applied Materials and Interfaces
Volume	13
Issue number	25
DOIs	https://doi.org/10.1021/acsami.1c05079
State	Published - 30 Jun 2021
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

cancer therapy
chemo-photothermal synergistic therapy
fluorescence imaging
imaging guiding
polydopamine-based carbon dots
tumor-targeted delivery

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10.1021/acsami.1c05079

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title = "Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor",

abstract = "We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.",

keywords = "cancer therapy, chemo-photothermal synergistic therapy, fluorescence imaging, imaging guiding, polydopamine-based carbon dots, tumor-targeted delivery",

author = "Zeyu Li and Jiatong Ni and Liping Liu and Liyuan Gu and Zhiguang Wu and Tianlong Li and Ivanovich, \{Krasnyuk Ivan\} and Wancheng Zhao and Tiedong Sun and Ting Wang",

note = "Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

year = "2021",

month = jun,

day = "30",

doi = "10.1021/acsami.1c05079",

language = "英语",

volume = "13",

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T1 - Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

AU - Li, Zeyu

AU - Ni, Jiatong

AU - Liu, Liping

AU - Gu, Liyuan

AU - Wu, Zhiguang

AU - Li, Tianlong

AU - Ivanovich, Krasnyuk Ivan

AU - Zhao, Wancheng

AU - Sun, Tiedong

AU - Wang, Ting

PY - 2021/6/30

Y1 - 2021/6/30

N2 - We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.

AB - We demonstrate a versatile nanoparticle with imaging-guided chemo-photothermal synergistic therapy and EpCAM-targeted delivery of liver tumor cells. EpCAM antibody (anti-EpCAM) and Pt(IV) were grafted onto the polydopamine carbon dots (PDA-CDs) by the amidation reaction. The EpCAM antibody of particles enables the targeted interaction with liver progenitor cells due to their overexpressed EpCAM protein. The tetravalent platinum prodrug [Pt(IV)] induces apoptosis with minimum toxic side effects through the interaction between cisplatin and tumor cell DNA. The nanoparticles displayed stable photothermal property and considerable anti-tumor therapeutic effect in vivo. Coupling with cellular imaging due to their fluorescence property, anti-EpCAM@PDA-CDs@Pt(IV) offers a convenient and effective platform for imaging-guided chemo-photothermal synergistic therapy toward liver cancers in the near future.

KW - cancer therapy

KW - chemo-photothermal synergistic therapy

KW - fluorescence imaging

KW - imaging guiding

KW - polydopamine-based carbon dots

KW - tumor-targeted delivery

UR - https://www.scopus.com/pages/publications/85110093162

U2 - 10.1021/acsami.1c05079

DO - 10.1021/acsami.1c05079

M3 - 文章

C2 - 34137582

AN - SCOPUS:85110093162

SN - 1944-8244

VL - 13

SP - 29340

EP - 29348

JO - ACS Applied Materials and Interfaces

JF - ACS Applied Materials and Interfaces

IS - 25

ER -

Imaging-Guided Chemo-Photothermal Polydopamine Carbon Dots for EpCAM-Targeted Delivery toward Liver Tumor

Abstract

UN SDGs

Keywords

Access to Document

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