Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology

Ming Shi; Pengfei Zhang; Setu M. Vora; Hao Wu

doi:10.1016/j.ceb.2020.03.002

Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology

Ming Shi
, Pengfei Zhang
, Setu M. Vora
, Hao Wu^*

^*Corresponding author for this work

Boston Children's Hospital
School of Life Science and Technology, Harbin Institute of Technology

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Higher-order supramolecular complexes–dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein–protein interactions or by dynamic liquid–liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.

Original language	English
Pages (from-to)	194-203
Number of pages	10
Journal	Current Opinion in Cell Biology
Volume	63
DOIs	https://doi.org/10.1016/j.ceb.2020.03.002
State	Published - Apr 2020
Externally published	Yes

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10.1016/j.ceb.2020.03.002

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title = "Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology",

abstract = "Higher-order supramolecular complexes{\textendash}dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein{\textendash}protein interactions or by dynamic liquid{\textendash}liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.",

author = "Ming Shi and Pengfei Zhang and Vora, \{Setu M.\} and Hao Wu",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",

year = "2020",

month = apr,

doi = "10.1016/j.ceb.2020.03.002",

language = "英语",

volume = "63",

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journal = "Current Opinion in Cell Biology",

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T1 - Higher-order assemblies in innate immune and inflammatory signaling

T2 - A general principle in cell biology

AU - Shi, Ming

AU - Zhang, Pengfei

AU - Vora, Setu M.

AU - Wu, Hao

PY - 2020/4

Y1 - 2020/4

N2 - Higher-order supramolecular complexes–dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein–protein interactions or by dynamic liquid–liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.

AB - Higher-order supramolecular complexes–dubbed signalosomes carry out key signaling and effector functions in innate immunity and inflammation. In this review, we present several recently discovered signalosomes that are formed either by stable protein–protein interactions or by dynamic liquid–liquid phase separation. Structural features of these signalosomes are highlighted to elucidate their functions and biological insights.

UR - https://www.scopus.com/pages/publications/85082761989

U2 - 10.1016/j.ceb.2020.03.002

DO - 10.1016/j.ceb.2020.03.002

M3 - 文献综述

C2 - 32272435

AN - SCOPUS:85082761989

SN - 0955-0674

VL - 63

SP - 194

EP - 203

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

ER -

Higher-order assemblies in innate immune and inflammatory signaling: A general principle in cell biology

Abstract

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