Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility

Liangyu Meng; Pengpeng Li; Yun Wang; Changlu Wang; Zhiwei Wang; Zhizhou Zhang

doi:10.1109/ICBBE.2009.5162878

Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility

Liangyu Meng^*
, Pengpeng Li
, Yun Wang
, Changlu Wang
, Zhiwei Wang
, Zhizhou Zhang

^*Corresponding author for this work

Tianjin University of Science & Technology
Shanghai Jiao Tong University

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

3 Scopus citations

Abstract

The relationship between alcohol consumption and onsets of breast cancer (BC) keeps obscure. A local gene network (LGN) was constructed using 24 breast cancer susceptibility genes that participate in known signal transduction pathways. It was found that the LGN was able to directly link several genes (ALDH, ADH1B and HDAC1) that have approved functions in alcohol metabolism. Further analysis indicated that the above three genes were associated with each other by other genes and metabolic molecules. Microarray data from 106 individual breast cancer patients and 4 normal people indicated that several key alcohol metabolism related genes were de-regulated and would induce genotypic combinations with the BC-specific LGN.

Original language	English
Title of host publication	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
DOIs	https://doi.org/10.1109/ICBBE.2009.5162878
State	Published - 2009
Externally published	Yes
Event	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 - Beijing, China Duration: 11 Jun 2009 → 13 Jun 2009

Publication series

Name	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

Conference

Conference	3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009
Country/Territory	China
City	Beijing
Period	11/06/09 → 13/06/09

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Alcohol consumption
Breast cancer
Local gene network
Microarray

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10.1109/ICBBE.2009.5162878

Cite this

Meng, L., Li, P., Wang, Y., Wang, C., Wang, Z., & Zhang, Z. (2009). Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility. In 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 Article 5162878 (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009). https://doi.org/10.1109/ICBBE.2009.5162878

@inproceedings{fc7165ae4b464e839596499f23e23c52,

title = "Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility",

abstract = "The relationship between alcohol consumption and onsets of breast cancer (BC) keeps obscure. A local gene network (LGN) was constructed using 24 breast cancer susceptibility genes that participate in known signal transduction pathways. It was found that the LGN was able to directly link several genes (ALDH, ADH1B and HDAC1) that have approved functions in alcohol metabolism. Further analysis indicated that the above three genes were associated with each other by other genes and metabolic molecules. Microarray data from 106 individual breast cancer patients and 4 normal people indicated that several key alcohol metabolism related genes were de-regulated and would induce genotypic combinations with the BC-specific LGN.",

keywords = "Alcohol consumption, Breast cancer, Local gene network, Microarray",

author = "Liangyu Meng and Pengpeng Li and Yun Wang and Changlu Wang and Zhiwei Wang and Zhizhou Zhang",

year = "2009",

doi = "10.1109/ICBBE.2009.5162878",

language = "英语",

isbn = "9781424429028",

series = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",

booktitle = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009",

note = "3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009 ; Conference date: 11-06-2009 Through 13-06-2009",

}

Meng, L, Li, P, Wang, Y, Wang, C, Wang, Z & Zhang, Z 2009, Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility. in 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009., 5162878, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009, Beijing, China, 11/06/09. https://doi.org/10.1109/ICBBE.2009.5162878

Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility. / Meng, Liangyu; Li, Pengpeng; Wang, Yun et al.
3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009. 5162878 (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility

AU - Meng, Liangyu

AU - Li, Pengpeng

AU - Wang, Yun

AU - Wang, Changlu

AU - Wang, Zhiwei

AU - Zhang, Zhizhou

PY - 2009

Y1 - 2009

N2 - The relationship between alcohol consumption and onsets of breast cancer (BC) keeps obscure. A local gene network (LGN) was constructed using 24 breast cancer susceptibility genes that participate in known signal transduction pathways. It was found that the LGN was able to directly link several genes (ALDH, ADH1B and HDAC1) that have approved functions in alcohol metabolism. Further analysis indicated that the above three genes were associated with each other by other genes and metabolic molecules. Microarray data from 106 individual breast cancer patients and 4 normal people indicated that several key alcohol metabolism related genes were de-regulated and would induce genotypic combinations with the BC-specific LGN.

AB - The relationship between alcohol consumption and onsets of breast cancer (BC) keeps obscure. A local gene network (LGN) was constructed using 24 breast cancer susceptibility genes that participate in known signal transduction pathways. It was found that the LGN was able to directly link several genes (ALDH, ADH1B and HDAC1) that have approved functions in alcohol metabolism. Further analysis indicated that the above three genes were associated with each other by other genes and metabolic molecules. Microarray data from 106 individual breast cancer patients and 4 normal people indicated that several key alcohol metabolism related genes were de-regulated and would induce genotypic combinations with the BC-specific LGN.

KW - Alcohol consumption

KW - Breast cancer

KW - Local gene network

KW - Microarray

UR - https://www.scopus.com/pages/publications/72749092255

U2 - 10.1109/ICBBE.2009.5162878

DO - 10.1109/ICBBE.2009.5162878

M3 - 会议稿件

AN - SCOPUS:72749092255

SN - 9781424429028

T3 - 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

BT - 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

T2 - 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009

Y2 - 11 June 2009 through 13 June 2009

ER -

Meng L, Li P, Wang Y, Wang C, Wang Z, Zhang Z. Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility. In 3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009. 2009. 5162878. (3rd International Conference on Bioinformatics and Biomedical Engineering, iCBBE 2009). doi: 10.1109/ICBBE.2009.5162878

Gene network study revealed molecular links among genes for alcohol metabolism and breast cancer susceptibility

Abstract

Publication series

Conference

UN SDGs

Keywords

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