Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin

Xian Hui Zhao; Liang Zhao; Yue Cheng Wu; Ya Jing Bian; Hui Jing Li; Yan Chao Wu

doi:10.1080/14786419.2025.2477813

Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin

Xian Hui Zhao
, Liang Zhao
, Yue Cheng Wu
, Ya Jing Bian
, Hui Jing Li
, Yan Chao Wu^*

^*Corresponding author for this work

Harbin Institute of Technology Weihai
Ltd.

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation of I to III via allylic oxidation and in situ hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.

Original language	English
Pages (from-to)	2573-2577
Number of pages	5
Journal	Natural Product Research
Volume	40
Issue number	9
DOIs	https://doi.org/10.1080/14786419.2025.2477813
State	Published - 2026
Externally published	Yes

Keywords

Natural product
divergent synthesis
isodrimenin
warburganal

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10.1080/14786419.2025.2477813

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title = "Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin",

abstract = "The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation of I to III via allylic oxidation and in situ hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.",

keywords = "Natural product, divergent synthesis, isodrimenin, warburganal",

author = "Zhao, \{Xian Hui\} and Liang Zhao and Wu, \{Yue Cheng\} and Bian, \{Ya Jing\} and Li, \{Hui Jing\} and Wu, \{Yan Chao\}",

note = "Publisher Copyright: {\textcopyright} 2025 Informa UK Limited, trading as Taylor \& Francis Group.",

year = "2026",

doi = "10.1080/14786419.2025.2477813",

language = "英语",

volume = "40",

pages = "2573--2577",

journal = "Natural Product Research",

issn = "1478-6419",

publisher = "Taylor and Francis Ltd.",

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TY - JOUR

T1 - Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin

AU - Zhao, Xian Hui

AU - Zhao, Liang

AU - Wu, Yue Cheng

AU - Bian, Ya Jing

AU - Li, Hui Jing

AU - Wu, Yan Chao

PY - 2026

Y1 - 2026

N2 - The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation of I to III via allylic oxidation and in situ hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.

AB - The formal divergent synthesis of natural products (−)-warburganal and synthesis of (+)-isodrimenin has been developed from α-hydroxy β,γ-unsaturated aldehyde I, which was easily prepared from available (+)-sclareolide in 5 steps. Reduction of intermediate I to II via an aldehyde reduction provides a 10-step access to (−)-warburganal, while oxidation of I to III via allylic oxidation and in situ hemiacetalization facilitates a 9-step synthesis of (+)-isodrimenin.

KW - Natural product

KW - divergent synthesis

KW - isodrimenin

KW - warburganal

UR - https://www.scopus.com/pages/publications/86000618434

U2 - 10.1080/14786419.2025.2477813

DO - 10.1080/14786419.2025.2477813

M3 - 文章

C2 - 40067952

AN - SCOPUS:86000618434

SN - 1478-6419

VL - 40

SP - 2573

EP - 2577

JO - Natural Product Research

JF - Natural Product Research

IS - 9

ER -

Formal synthesis of (-)-warburganal and synthesis of (+)-isodrimenin

Abstract

Keywords

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