Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Yue Wang; Wanqian Guo; Bor Yann Chen; Chieh Lun Cheng; Yung Chung Lo; Shih Hsin Ho; Jo Shu Chang; Nanqi Ren

doi:10.1016/j.biortech.2015.09.075

Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Yue Wang
, Wanqian Guo
, Bor Yann Chen
, Chieh Lun Cheng
, Yung Chung Lo
, Shih Hsin Ho
, Jo Shu Chang^*
, Nanqi Ren

^*Corresponding author for this work

School of Environment

Harbin Institute of Technology
National Ilan University Taiwan
National Cheng Kung University

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na₂SO₄. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na₂SO₄ appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.

Original language	English
Pages (from-to)	571-576
Number of pages	6
Journal	Bioresource Technology
Volume	198
DOIs	https://doi.org/10.1016/j.biortech.2015.09.075
State	Published - 1 Dec 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 7 Affordable and Clean Energy

Keywords

Butanol fermentation
Dose response
Probit analysis
Toxicity

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10.1016/j.biortech.2015.09.075

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title = "Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment",

abstract = "This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na2SO4. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na2SO4 appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.",

keywords = "Butanol fermentation, Dose response, Probit analysis, Toxicity",

author = "Yue Wang and Wanqian Guo and Chen, \{Bor Yann\} and Cheng, \{Chieh Lun\} and Lo, \{Yung Chung\} and Ho, \{Shih Hsin\} and Chang, \{Jo Shu\} and Nanqi Ren",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.biortech.2015.09.075",

language = "英语",

volume = "198",

pages = "571--576",

journal = "Bioresource Technology",

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T1 - Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation

T2 - A toxicological assessment

AU - Wang, Yue

AU - Guo, Wanqian

AU - Chen, Bor Yann

AU - Cheng, Chieh Lun

AU - Lo, Yung Chung

AU - Ho, Shih Hsin

AU - Chang, Jo Shu

AU - Ren, Nanqi

PY - 2015/12/1

Y1 - 2015/12/1

N2 - This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na2SO4. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na2SO4 appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.

AB - This study aimed to quantitatively evaluate the inhibitor tolerance of butanol-producing bacterium Clostridium acetobutylicum. The inhibitory effect of the inhibitors generated by acid pretreatment of biomass feedstock on butanol fermentation decreased in the order of formic acid > oxalic acid > furfural > 5-HMF > Na2SO4. C. acetobutylicum has a small tolerance range for furfural (1.06-2.6g/L) and 5-HMF (1.99-2.3g/L). However, the inhibitory effect of Na2SO4 appears to have a wide range, with a chronic toxicity for C. acetobutylicum. All the results could explain, in quantitative manner, the instability of butanol fermentation with C. acetobutylicum from various acid-pretreated feedstocks caused by the fermentation inhibitors.

KW - Butanol fermentation

KW - Dose response

KW - Probit analysis

KW - Toxicity

UR - https://www.scopus.com/pages/publications/84943164520

U2 - 10.1016/j.biortech.2015.09.075

DO - 10.1016/j.biortech.2015.09.075

M3 - 文章

C2 - 26433154

AN - SCOPUS:84943164520

SN - 0960-8524

VL - 198

SP - 571

EP - 576

JO - Bioresource Technology

JF - Bioresource Technology

ER -

Exploring the inhibitory characteristics of acid hydrolysates upon butanol fermentation: A toxicological assessment

Abstract

UN SDGs

Keywords

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