Enhancement of silymarin solubility and bioactivities using betaine/ascorbyl glucoside DES

Yuanbin Li; Yi Wu; Haowei Chen; Bao Han; Bo Ruan; Xiaoyu Zhong; Shanshan Li; Yifan Chen; Tao Peng; Jiaheng Zhang; Fang Wang

doi:10.1039/d4nj03748k

Enhancement of silymarin solubility and bioactivities using betaine/ascorbyl glucoside DES

Yuanbin Li
, Yi Wu
, Haowei Chen
, Bao Han
, Bo Ruan
, Xiaoyu Zhong
, Shanshan Li
, Yifan Chen
, Tao Peng
, Jiaheng Zhang^*
, Fang Wang^*

^*Corresponding author for this work

Shenzhen Shinehigh Innovation Technology Co., Ltd.
Ltd
Harbin Institute of Technology Shenzhen
Harbin Institute of Technology (Shenzhen)

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Betaine/ascorbyl glucoside (Bet/AA-2G) deep eutectic solvent (DES) composed of betaine and ascorbyl glucoside have been successfully used to improve the solubility of silymarin in this study. Under appropriate conditions, the solubility of silymarin in a 5 wt% Bet/AA-2G DES solution increased by 17.7% and 60.9% compared to a 50 wt% 1,3-butanediol solution and a 50 wt% ethanol solution, respectively. In addition, quantum chemical simulations showed that silymarin had a strong binding capacity to Bet/AA-2G DES and can remain stable after binding. The combination of Bet/AA-2G DES with silymarin enhanced the skin permeability and antioxidant capacity of silymarin. Moreover, Silymarin extract extracted from a mixture of DES (50 wt%) (SM-DES) promoted the synthesis of type I collagen and significantly reduced the expression of MMP-1, indicating potential anti-wrinkle and firming properties. Overall, Bet/AA-2G DES showed great potential for improving the solubility and stabilizing the bioactivity of silymarin.

Original language	English
Pages (from-to)	174-182
Number of pages	9
Journal	New Journal of Chemistry
Volume	49
Issue number	1
DOIs	https://doi.org/10.1039/d4nj03748k
State	Published - 21 Nov 2024
Externally published	Yes

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@article{e83d34ed4b5d4bf7bd556834e0deaa44,

title = "Enhancement of silymarin solubility and bioactivities using betaine/ascorbyl glucoside DES",

abstract = "Betaine/ascorbyl glucoside (Bet/AA-2G) deep eutectic solvent (DES) composed of betaine and ascorbyl glucoside have been successfully used to improve the solubility of silymarin in this study. Under appropriate conditions, the solubility of silymarin in a 5 wt\% Bet/AA-2G DES solution increased by 17.7\% and 60.9\% compared to a 50 wt\% 1,3-butanediol solution and a 50 wt\% ethanol solution, respectively. In addition, quantum chemical simulations showed that silymarin had a strong binding capacity to Bet/AA-2G DES and can remain stable after binding. The combination of Bet/AA-2G DES with silymarin enhanced the skin permeability and antioxidant capacity of silymarin. Moreover, Silymarin extract extracted from a mixture of DES (50 wt\%) (SM-DES) promoted the synthesis of type I collagen and significantly reduced the expression of MMP-1, indicating potential anti-wrinkle and firming properties. Overall, Bet/AA-2G DES showed great potential for improving the solubility and stabilizing the bioactivity of silymarin.",

author = "Yuanbin Li and Yi Wu and Haowei Chen and Bao Han and Bo Ruan and Xiaoyu Zhong and Shanshan Li and Yifan Chen and Tao Peng and Jiaheng Zhang and Fang Wang",

note = "Publisher Copyright: {\textcopyright} 2025 The Royal Society of Chemistry.",

year = "2024",

month = nov,

day = "21",

doi = "10.1039/d4nj03748k",

language = "英语",

volume = "49",

pages = "174--182",

journal = "New Journal of Chemistry",

issn = "1144-0546",

publisher = "Royal Society of Chemistry",

number = "1",

}

TY - JOUR

T1 - Enhancement of silymarin solubility and bioactivities using betaine/ascorbyl glucoside DES

AU - Li, Yuanbin

AU - Wu, Yi

AU - Chen, Haowei

AU - Han, Bao

AU - Ruan, Bo

AU - Zhong, Xiaoyu

AU - Li, Shanshan

AU - Chen, Yifan

AU - Peng, Tao

AU - Zhang, Jiaheng

AU - Wang, Fang

PY - 2024/11/21

Y1 - 2024/11/21

N2 - Betaine/ascorbyl glucoside (Bet/AA-2G) deep eutectic solvent (DES) composed of betaine and ascorbyl glucoside have been successfully used to improve the solubility of silymarin in this study. Under appropriate conditions, the solubility of silymarin in a 5 wt% Bet/AA-2G DES solution increased by 17.7% and 60.9% compared to a 50 wt% 1,3-butanediol solution and a 50 wt% ethanol solution, respectively. In addition, quantum chemical simulations showed that silymarin had a strong binding capacity to Bet/AA-2G DES and can remain stable after binding. The combination of Bet/AA-2G DES with silymarin enhanced the skin permeability and antioxidant capacity of silymarin. Moreover, Silymarin extract extracted from a mixture of DES (50 wt%) (SM-DES) promoted the synthesis of type I collagen and significantly reduced the expression of MMP-1, indicating potential anti-wrinkle and firming properties. Overall, Bet/AA-2G DES showed great potential for improving the solubility and stabilizing the bioactivity of silymarin.

AB - Betaine/ascorbyl glucoside (Bet/AA-2G) deep eutectic solvent (DES) composed of betaine and ascorbyl glucoside have been successfully used to improve the solubility of silymarin in this study. Under appropriate conditions, the solubility of silymarin in a 5 wt% Bet/AA-2G DES solution increased by 17.7% and 60.9% compared to a 50 wt% 1,3-butanediol solution and a 50 wt% ethanol solution, respectively. In addition, quantum chemical simulations showed that silymarin had a strong binding capacity to Bet/AA-2G DES and can remain stable after binding. The combination of Bet/AA-2G DES with silymarin enhanced the skin permeability and antioxidant capacity of silymarin. Moreover, Silymarin extract extracted from a mixture of DES (50 wt%) (SM-DES) promoted the synthesis of type I collagen and significantly reduced the expression of MMP-1, indicating potential anti-wrinkle and firming properties. Overall, Bet/AA-2G DES showed great potential for improving the solubility and stabilizing the bioactivity of silymarin.

UR - https://www.scopus.com/pages/publications/85210945755

U2 - 10.1039/d4nj03748k

DO - 10.1039/d4nj03748k

M3 - 文章

AN - SCOPUS:85210945755

SN - 1144-0546

VL - 49

SP - 174

EP - 182

JO - New Journal of Chemistry

JF - New Journal of Chemistry

IS - 1

ER -

Enhancement of silymarin solubility and bioactivities using betaine/ascorbyl glucoside DES

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