Electrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions

Lei Wang; Xiao Zhang; Raymond Yang Xia; Chao Yang; Lin Guo; Wujiong Xia

doi:10.1055/a-1833-9025

Electrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions

Lei Wang
, Xiao Zhang
, Raymond Yang Xia
, Chao Yang^*
, Lin Guo^*
, Wujiong Xia

^*Corresponding author for this work

Harbin Institute of Technology Shenzhen
Shenzhen University
Henan Normal University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A sustainable, practical, and direct strategy for the reduction of carbonyl compounds, including aldehydes and ketones, by an electrochemical pathway is presented, affording a variety of alcohols or diols as major products with decent yields. The reaction proceeds smoothly in the air at ambient temperatures with DABCO as the sacrificial reductant. Mechanistic studies revealed that direct electrochemical reduction followed by either protonation or radical radical homocoupling is the main pathway.

Original language	English
Article number	st-2022-v0138-l
Pages (from-to)	1302-1308
Number of pages	7
Journal	Synlett
Volume	33
Issue number	13
DOIs	https://doi.org/10.1055/a-1833-9025
State	Published - 17 May 2022
Externally published	Yes

Keywords

alcohols
carbonyl compounds
electrochemistry
pinacols
reduction
transition-metal-free

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10.1055/a-1833-9025

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abstract = "A sustainable, practical, and direct strategy for the reduction of carbonyl compounds, including aldehydes and ketones, by an electrochemical pathway is presented, affording a variety of alcohols or diols as major products with decent yields. The reaction proceeds smoothly in the air at ambient temperatures with DABCO as the sacrificial reductant. Mechanistic studies revealed that direct electrochemical reduction followed by either protonation or radical radical homocoupling is the main pathway.",

keywords = "alcohols, carbonyl compounds, electrochemistry, pinacols, reduction, transition-metal-free",

author = "Lei Wang and Xiao Zhang and Xia, \{Raymond Yang\} and Chao Yang and Lin Guo and Wujiong Xia",

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T1 - Electrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions

AU - Wang, Lei

AU - Zhang, Xiao

AU - Xia, Raymond Yang

AU - Yang, Chao

AU - Guo, Lin

AU - Xia, Wujiong

PY - 2022/5/17

Y1 - 2022/5/17

N2 - A sustainable, practical, and direct strategy for the reduction of carbonyl compounds, including aldehydes and ketones, by an electrochemical pathway is presented, affording a variety of alcohols or diols as major products with decent yields. The reaction proceeds smoothly in the air at ambient temperatures with DABCO as the sacrificial reductant. Mechanistic studies revealed that direct electrochemical reduction followed by either protonation or radical radical homocoupling is the main pathway.

AB - A sustainable, practical, and direct strategy for the reduction of carbonyl compounds, including aldehydes and ketones, by an electrochemical pathway is presented, affording a variety of alcohols or diols as major products with decent yields. The reaction proceeds smoothly in the air at ambient temperatures with DABCO as the sacrificial reductant. Mechanistic studies revealed that direct electrochemical reduction followed by either protonation or radical radical homocoupling is the main pathway.

KW - alcohols

KW - carbonyl compounds

KW - electrochemistry

KW - pinacols

KW - reduction

KW - transition-metal-free

UR - https://www.scopus.com/pages/publications/85136104525

U2 - 10.1055/a-1833-9025

DO - 10.1055/a-1833-9025

M3 - 文章

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SN - 0936-5214

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SP - 1302

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JO - Synlett

JF - Synlett

IS - 13

M1 - st-2022-v0138-l

ER -

Electrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions

Abstract

Keywords

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