Effect of micropores and citric acid on the bioactivity of phosphorylated chitosan/chitosan/hydroxyapatite composites

Bin Li; Longnan Huang; Xinbo Wang; Jinhuan Ma; Fang Xie; Long Xia

doi:10.1016/j.ceramint.2012.09.069

Effect of micropores and citric acid on the bioactivity of phosphorylated chitosan/chitosan/hydroxyapatite composites

Bin Li
, Longnan Huang
, Xinbo Wang^*
, Jinhuan Ma
, Fang Xie
, Long Xia

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

The phosphorylated chitosan/chitosan/hydroxyapatite (PCS/CS/HA) bio-composite was synthesized by the coprecipitation method, and the effect of micropores and citric acid on its bioactivity was studied via simulated body fluid (SBF). The PCS had been successfully prepared by introducing the phosphate groups into CS. After the aging process, the crystallinity of HA became higher. The CO₃^2- groups in PCS/CS/HA composite showed that the HA obtained in this study was carbonate apatite. After soaking in SBF for 21 days, the Ca/P molar ratios of unpolished PCS/CS/HA sheet increased from 1.28 to 1.53, which was closer to that of HA. In addition, the unpolished composite sheet soaked in SBF with citric acid presented a better bioactivity.

Original language	English
Pages (from-to)	3423-3427
Number of pages	5
Journal	Ceramics International
Volume	39
Issue number	3
DOIs	https://doi.org/10.1016/j.ceramint.2012.09.069
State	Published - Apr 2013
Externally published	Yes

Keywords

Biomedical applications
Chitosan
Composites
Surfaces

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10.1016/j.ceramint.2012.09.069

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title = "Effect of micropores and citric acid on the bioactivity of phosphorylated chitosan/chitosan/hydroxyapatite composites",

abstract = "The phosphorylated chitosan/chitosan/hydroxyapatite (PCS/CS/HA) bio-composite was synthesized by the coprecipitation method, and the effect of micropores and citric acid on its bioactivity was studied via simulated body fluid (SBF). The PCS had been successfully prepared by introducing the phosphate groups into CS. After the aging process, the crystallinity of HA became higher. The CO32- groups in PCS/CS/HA composite showed that the HA obtained in this study was carbonate apatite. After soaking in SBF for 21 days, the Ca/P molar ratios of unpolished PCS/CS/HA sheet increased from 1.28 to 1.53, which was closer to that of HA. In addition, the unpolished composite sheet soaked in SBF with citric acid presented a better bioactivity.",

keywords = "Biomedical applications, Chitosan, Composites, Surfaces",

author = "Bin Li and Longnan Huang and Xinbo Wang and Jinhuan Ma and Fang Xie and Long Xia",

year = "2013",

month = apr,

doi = "10.1016/j.ceramint.2012.09.069",

language = "英语",

volume = "39",

pages = "3423--3427",

journal = "Ceramics International",

issn = "0272-8842",

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}

TY - JOUR

T1 - Effect of micropores and citric acid on the bioactivity of phosphorylated chitosan/chitosan/hydroxyapatite composites

AU - Li, Bin

AU - Huang, Longnan

AU - Wang, Xinbo

AU - Ma, Jinhuan

AU - Xie, Fang

AU - Xia, Long

PY - 2013/4

Y1 - 2013/4

N2 - The phosphorylated chitosan/chitosan/hydroxyapatite (PCS/CS/HA) bio-composite was synthesized by the coprecipitation method, and the effect of micropores and citric acid on its bioactivity was studied via simulated body fluid (SBF). The PCS had been successfully prepared by introducing the phosphate groups into CS. After the aging process, the crystallinity of HA became higher. The CO32- groups in PCS/CS/HA composite showed that the HA obtained in this study was carbonate apatite. After soaking in SBF for 21 days, the Ca/P molar ratios of unpolished PCS/CS/HA sheet increased from 1.28 to 1.53, which was closer to that of HA. In addition, the unpolished composite sheet soaked in SBF with citric acid presented a better bioactivity.

AB - The phosphorylated chitosan/chitosan/hydroxyapatite (PCS/CS/HA) bio-composite was synthesized by the coprecipitation method, and the effect of micropores and citric acid on its bioactivity was studied via simulated body fluid (SBF). The PCS had been successfully prepared by introducing the phosphate groups into CS. After the aging process, the crystallinity of HA became higher. The CO32- groups in PCS/CS/HA composite showed that the HA obtained in this study was carbonate apatite. After soaking in SBF for 21 days, the Ca/P molar ratios of unpolished PCS/CS/HA sheet increased from 1.28 to 1.53, which was closer to that of HA. In addition, the unpolished composite sheet soaked in SBF with citric acid presented a better bioactivity.

KW - Biomedical applications

KW - Chitosan

KW - Composites

KW - Surfaces

UR - https://www.scopus.com/pages/publications/84872937895

U2 - 10.1016/j.ceramint.2012.09.069

DO - 10.1016/j.ceramint.2012.09.069

M3 - 文章

AN - SCOPUS:84872937895

SN - 0272-8842

VL - 39

SP - 3423

EP - 3427

JO - Ceramics International

JF - Ceramics International

IS - 3

ER -

Effect of micropores and citric acid on the bioactivity of phosphorylated chitosan/chitosan/hydroxyapatite composites

Abstract

Keywords

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