Effect of equol of a isoflavone metabolite on menopausal symptoms

OBJECTIVE: To explore the effect of equol of a isoflavone metabolite on menopausal women and the menopausal syndrome. METHODS: 71 menopausal women living in Harbin were assessed, and the participants were at the age of 45-55 years. The concentrations of Isoflavone and equol in first-void morning urines were analyzed by HPLC. All participants completed Kupperman questionnaire tables which were used to evaluate the severity of menopausal symptoms. The association between the equol concentrations in menopausal women and the menopausal syndrome were examine by statistical analysis method. RESULTS: The negative association between the urinary equol concentrations and the menopausal index score (P < 0.05) were found, and the negative correlation only exists in EP group after grouping at the concentration of 0.5 microg/ml equol. CONCLUSION: It was suggested that it were more higher of urinary equol concentration in menopausal women, more less of the menopausal symptoms.