Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

Xing Ma; Onn Shaun Ong; Yanli Zhao

doi:10.1039/c3bm60090d

Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

Xing Ma
, Onn Shaun Ong
, Yanli Zhao^*

^*Corresponding author for this work

Nanyang Technological University

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.

Original language	English
Pages (from-to)	912-917
Number of pages	6
Journal	Biomaterials Science
Volume	1
Issue number	9
DOIs	https://doi.org/10.1039/c3bm60090d
State	Published - Sep 2013
Externally published	Yes

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10.1039/c3bm60090d

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title = "Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles",

abstract = "Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.",

author = "Xing Ma and Ong, \{Onn Shaun\} and Yanli Zhao",

year = "2013",

month = sep,

doi = "10.1039/c3bm60090d",

language = "英语",

volume = "1",

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journal = "Biomaterials Science",

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publisher = "Royal Society of Chemistry",

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AU - Ma, Xing

AU - Ong, Onn Shaun

AU - Zhao, Yanli

PY - 2013/9

Y1 - 2013/9

N2 - Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.

AB - Mesoporous silica nanoparticles (MSNPs) are functionalized with 15-mer single-stranded DNA (ssDNA). After loading of doxorubicin, functionalized MSNPs are capped with 33-mer complementary ssDNA through the formation of double-stranded DNA. Encapsulated doxorubicin could be released by either thermal-triggered denaturization of the DNA capping chains or redox-induced disulfide bond cleavage. An in vitro study shows successful delivery of doxorubicin into HeLa cells.

UR - https://www.scopus.com/pages/publications/84881074209

U2 - 10.1039/c3bm60090d

DO - 10.1039/c3bm60090d

M3 - 文章

AN - SCOPUS:84881074209

SN - 2047-4830

VL - 1

SP - 912

EP - 917

JO - Biomaterials Science

JF - Biomaterials Science

IS - 9

ER -

Dual-responsive drug release from oligonucleotide-capped mesoporous silica nanoparticles

Abstract

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