Dual active nanozyme-loaded MXene enables hyperthermia-enhanced tumor nanocatalytic therapy

Nanozymes, which have enzymatic activity and physicochemical properties of nanomaterials, have attracted extensive attention in the field of tumor therapy. However, the low activity of nanozymes in the tumor microenvironment leads to limited therapeutic effects. Here, we report an MXene-integrated nanozyme that exhibits dual catalytic activities, exerting synergistic effects to enhance tumor therapy. The MXene-integrated nanozyme consists of CeO₂ nanozymes with dual enzyme-like activities (simulating catalase and peroxidase) loaded on MXene. In such a construct, the catalase- and peroxidase-like activity of CeO₂ nanozymes alleviates hypoxia and elevates oxidative stress in the tumor microenvironment, and the overexpressed glutathione (GSH) is consumed by the redox reaction of CeO₂ nanozymes. The CeO₂ nanozyme-loaded MXene could couple the photothermal effect and dual enzyme-like activities, resulting in enhanced tumor nanocatalytic therapy with a tumor growth inhibition (TGI) effect of 92%. Dual active nanozyme-loaded MXene is a promising material for the development of nanozyme catalytic therapy in the future.