Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates

Qing Xuan Zheng; Rui Wang; Hui Jing Li; Wim Dehaen; Qi Yong Huai

doi:10.1007/s11094-024-03023-2

Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates

Qing Xuan Zheng
, Rui Wang
, Hui Jing Li
, Wim Dehaen
, Qi Yong Huai^*

^*Corresponding author for this work

Shandong University
KU Leuven
School of Marine Science and Technology, Harbin Institute of Technology Weihai

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Oleanolic acid (OA) is a natural product with certain antitumor activity. In order to enhance its cytotoxicity, a total of five derivatives of OA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer cells), A549 cells (human nonsmall cell lung cancer cells) and BEAS-2B cells (human cervical cancer cells) were evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results indicated that these target compounds have a wide molar activity range and some of them showed better activity than the commercial drug, doxorubicin. Compound 2a induces apoptosis of 14, 27, and 56% of MDA-MB-231 cells at 2, 4, and 8 mM respectively, and shows a linear correlation of concentration.

Original language	English
Pages (from-to)	1174-1178
Number of pages	5
Journal	Pharmaceutical Chemistry Journal
Volume	57
Issue number	8
DOIs	https://doi.org/10.1007/s11094-024-03023-2
State	Published - Nov 2023
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

apoptosis
cytotoxicity
oleanolic acid

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10.1007/s11094-024-03023-2

Cite this

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title = "Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates",

abstract = "Oleanolic acid (OA) is a natural product with certain antitumor activity. In order to enhance its cytotoxicity, a total of five derivatives of OA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer cells), A549 cells (human nonsmall cell lung cancer cells) and BEAS-2B cells (human cervical cancer cells) were evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results indicated that these target compounds have a wide molar activity range and some of them showed better activity than the commercial drug, doxorubicin. Compound 2a induces apoptosis of 14, 27, and 56\% of MDA-MB-231 cells at 2, 4, and 8 mM respectively, and shows a linear correlation of concentration.",

keywords = "apoptosis, cytotoxicity, oleanolic acid",

author = "Zheng, \{Qing Xuan\} and Rui Wang and Li, \{Hui Jing\} and Wim Dehaen and Huai, \{Qi Yong\}",

note = "Publisher Copyright: {\textcopyright} 2024, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2023",

month = nov,

doi = "10.1007/s11094-024-03023-2",

language = "英语",

volume = "57",

pages = "1174--1178",

journal = "Pharmaceutical Chemistry Journal",

issn = "0091-150X",

publisher = "Springer New York",

number = "8",

}

TY - JOUR

T1 - Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates

AU - Zheng, Qing Xuan

AU - Wang, Rui

AU - Li, Hui Jing

AU - Dehaen, Wim

AU - Huai, Qi Yong

PY - 2023/11

Y1 - 2023/11

N2 - Oleanolic acid (OA) is a natural product with certain antitumor activity. In order to enhance its cytotoxicity, a total of five derivatives of OA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer cells), A549 cells (human nonsmall cell lung cancer cells) and BEAS-2B cells (human cervical cancer cells) were evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results indicated that these target compounds have a wide molar activity range and some of them showed better activity than the commercial drug, doxorubicin. Compound 2a induces apoptosis of 14, 27, and 56% of MDA-MB-231 cells at 2, 4, and 8 mM respectively, and shows a linear correlation of concentration.

AB - Oleanolic acid (OA) is a natural product with certain antitumor activity. In order to enhance its cytotoxicity, a total of five derivatives of OA were designed and synthesized. Their cytotoxicity against MDA-MB-231cells (human breast cancer cells), A549 cells (human nonsmall cell lung cancer cells) and BEAS-2B cells (human cervical cancer cells) were evaluated by the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) method. The results indicated that these target compounds have a wide molar activity range and some of them showed better activity than the commercial drug, doxorubicin. Compound 2a induces apoptosis of 14, 27, and 56% of MDA-MB-231 cells at 2, 4, and 8 mM respectively, and shows a linear correlation of concentration.

KW - apoptosis

KW - cytotoxicity

KW - oleanolic acid

UR - https://www.scopus.com/pages/publications/85181250240

U2 - 10.1007/s11094-024-03023-2

DO - 10.1007/s11094-024-03023-2

M3 - 文章

AN - SCOPUS:85181250240

SN - 0091-150X

VL - 57

SP - 1174

EP - 1178

JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 8

ER -

Design, Preparation and Studies Regarding Cytotoxic Properties of Benzyl Oleanates

Abstract

UN SDGs

Keywords

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