Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids

Rui Wang; Qing Xuan Zheng; Wei Wang; Ling Feng; Hui Jing Li; Qi Yong Huai

doi:10.1248/bpb.b17-00016

Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids

Rui Wang
, Qing Xuan Zheng
, Wei Wang
, Ling Feng
, Hui Jing Li^*
, Qi Yong Huai

^*Corresponding author for this work

Shandong University
City University of Hong Kong
School of Marine Science and Technology, Harbin Institute of Technology Weihai

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC₅₀ values of 23.34 μM on Hep-G2 cells, 12.23 μM on MCF-7 cells, and 44.47 μM on LO2, which would widen the structural diversity of these anticancer targets and confirm the perspectives of further investigations.

Original language	English
Pages (from-to)	703-710
Number of pages	8
Journal	Biological and Pharmaceutical Bulletin
Volume	40
Issue number	5
DOIs	https://doi.org/10.1248/bpb.b17-00016
State	Published - 2017
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Anticancer
Glycyrrhetinic acid
Oleanolic acid
Synthesis

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10.1248/bpb.b17-00016

Cite this

@article{239a287b975044e3b07ba6af1495e15b,

title = "Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids",

abstract = "A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC50 values of 23.34 μM on Hep-G2 cells, 12.23 μM on MCF-7 cells, and 44.47 μM on LO2, which would widen the structural diversity of these anticancer targets and confirm the perspectives of further investigations.",

keywords = "Anticancer, Glycyrrhetinic acid, Oleanolic acid, Synthesis",

author = "Rui Wang and Zheng, \{Qing Xuan\} and Wei Wang and Ling Feng and Li, \{Hui Jing\} and Huai, \{Qi Yong\}",

note = "Publisher Copyright: {\textcopyright} 2017 The Pharmaceutical Society of Japan.",

year = "2017",

doi = "10.1248/bpb.b17-00016",

language = "英语",

volume = "40",

pages = "703--710",

journal = "Biological and Pharmaceutical Bulletin",

issn = "0918-6158",

publisher = "Pharmaceutical Society of Japan",

number = "5",

}

TY - JOUR

T1 - Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids

AU - Wang, Rui

AU - Zheng, Qing Xuan

AU - Wang, Wei

AU - Feng, Ling

AU - Li, Hui Jing

AU - Huai, Qi Yong

PY - 2017

Y1 - 2017

N2 - A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC50 values of 23.34 μM on Hep-G2 cells, 12.23 μM on MCF-7 cells, and 44.47 μM on LO2, which would widen the structural diversity of these anticancer targets and confirm the perspectives of further investigations.

AB - A series of new glycyrrhetinic acids and oleanolic acids has been designed and synthesized based on the principles of combinatorial chemical synthesis. Their anticancer activities were further studied by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method with hepatocellular carcinoma (Hep-G2), breast cancer (MCF-7) cell lines and a normal hepatic cell (LO2). Cytotoxicity tests (in vitro) indicated that compound 6a showed the highest cytotoxicity with the lowest IC50 values of 23.34 μM on Hep-G2 cells, 12.23 μM on MCF-7 cells, and 44.47 μM on LO2, which would widen the structural diversity of these anticancer targets and confirm the perspectives of further investigations.

KW - Anticancer

KW - Glycyrrhetinic acid

KW - Oleanolic acid

KW - Synthesis

UR - https://www.scopus.com/pages/publications/85019209037

U2 - 10.1248/bpb.b17-00016

DO - 10.1248/bpb.b17-00016

M3 - 文章

C2 - 28458357

AN - SCOPUS:85019209037

SN - 0918-6158

VL - 40

SP - 703

EP - 710

JO - Biological and Pharmaceutical Bulletin

JF - Biological and Pharmaceutical Bulletin

IS - 5

ER -

Design and synthesis of new anticancer glycyrrhetinic acids and oleanolic acids

Abstract

UN SDGs

Keywords

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