COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Xianwen Ren; Wen Wen; Xiaoying Fan; Wenhong Hou; Bin Su; Pengfei Cai; Jiesheng Li; Yang Liu; Fei Tang; Fan Zhang; Yu Yang; Jiangping He; Wenji Ma; Jingjing He; Pingping Wang; Qiqi Cao; Fangjin Chen; Yuqing Chen; Xuelian Cheng; Guohong Deng; Xilong Deng; Wenyu Ding; Yingmei Feng; Rui Gan; Chuang Guo; Weiqiang Guo; Shuai He; Chen Jiang; Juanran Liang; Yi min Li; Jun Lin; Yun Ling; Haofei Liu; Jianwei Liu; Nianping Liu; Shu Qiang Liu; Meng Luo; Qiang Ma; Qibing Song; Wujianan Sun; Gao Xiang Wang; Feng Wang; Ying Wang; Xiaofeng Wen; Qian Wu; Gang Xu; Xiaowei Xie; Xinxin Xiong; Xudong Xing; Hao Xu; Chonghai Yin; Dongdong Yu; Kezhuo Yu; Jin Yuan; Biao Zhang; Peipei Zhang; Tong Zhang; Jincun Zhao; Peidong Zhao; Jianfeng Zhou; Wei Zhou; Sujuan Zhong; Xiaosong Zhong; Shuye Zhang; Lin Zhu; Ping Zhu; Bin Zou; Jiahua Zou; Zengtao Zuo; Fan Bai; Xi Huang; Penghui Zhou; Qinghua Jiang; Zhiwei Huang; Jin Xin Bei; Lai Wei; Xiu Wu Bian; Xindong Liu; Tao Cheng; Xiangpan Li; Pingsen Zhao; Fu Sheng Wang; Hongyang Wang; Bing Su; Zheng Zhang; Kun Qu; Xiaoqun Wang; Jiekai Chen; Ronghua Jin; Zemin Zhang

doi:10.1016/j.cell.2021.01.053

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Xianwen Ren
, Wen Wen
, Xiaoying Fan
, Wenhong Hou
, Bin Su
, Pengfei Cai
, Jiesheng Li
, Yang Liu
, Fei Tang
, Fan Zhang
, Yu Yang
, Jiangping He
, Wenji Ma
, Jingjing He
, Pingping Wang
, Qiqi Cao
, Fangjin Chen
, Yuqing Chen
, Xuelian Cheng
, Guohong Deng

Xilong Deng, Wenyu Ding, Yingmei Feng, Rui Gan, Chuang Guo, Weiqiang Guo, Shuai He, Chen Jiang, Juanran Liang, Yi min Li, Jun Lin, Yun Ling, Haofei Liu, Jianwei Liu, Nianping Liu, Shu Qiang Liu, Meng Luo, Qiang Ma, Qibing Song, Wujianan Sun, Gao Xiang Wang, Feng Wang, Ying Wang, Xiaofeng Wen, Qian Wu, Gang Xu, Xiaowei Xie, Xinxin Xiong, Xudong Xing, Hao Xu, Chonghai Yin, Dongdong Yu, Kezhuo Yu, Jin Yuan, Biao Zhang, Peipei Zhang, Tong Zhang, Jincun Zhao, Peidong Zhao, Jianfeng Zhou, Wei Zhou, Sujuan Zhong, Xiaosong Zhong, Shuye Zhang, Lin Zhu, Ping Zhu, Bin Zou, Jiahua Zou, Zengtao Zuo, Fan Bai, Xi Huang, Penghui Zhou^*, Qinghua Jiang^*, Zhiwei Huang^*, Jin Xin Bei^*, Lai Wei^*, Xiu Wu Bian^*, Xindong Liu^*, Tao Cheng^*, Xiangpan Li^*, Pingsen Zhao^*, Fu Sheng Wang^*, Hongyang Wang^*, Bing Su^*, Zheng Zhang^*, Kun Qu^*, Xiaoqun Wang^*, Jiekai Chen^*, Ronghua Jin^*, Zemin Zhang^*

^*Corresponding author for this work

Peking University
Naval Medical University
Bioland Laboratory (Guangzhou Regenerative Medicine and Health GuangDong Laboratory)
Chinese Academy of Sciences
Shenzhen Bay Laboratory
Capital Medical University
University of Science and Technology of China
Southern University of Science and Technology
School of Life Science and Technology, Harbin Institute of Technology
Sun Yat-Sen University Cancer Center
Chinese Academy of Medical Sciences
Chongqing Medical University
Guangzhou Medical College
Beijing Normal University
Shantou University
Sun Yat-Sen University
The First Affiliated Hospital of Guangzhou Medical University
Shanghai Public Health clinical Center
Renmin Hospital of Wuhan University
Huazhong University of Science and Technology
Shanghai Jiao Tong University
General Hospital of People's Liberation Army
Analytical Biosciences Beijing Limited
Fudan University
Huanggang Hospital of Traditional Chinese Medicine
The Fifth Affiliated Hospital Sun Yat-sen University
CAS - Guangzhou Institute of Biomedicine and Health

Research output: Contribution to journal › Article › peer-review

655 Scopus citations

Abstract

Analysis of the immune landscape in the lung and peripheral blood of COVID patients across different regions in China at the single-cell level documents the presence of viral RNAs in diverse cell types and highlights the potential contribution of megakaryocytes and monocyte subsets to cytokine storms.

Original language	English
Pages (from-to)	1895-1913.e19
Journal	Cell
Volume	184
Issue number	7
DOIs	https://doi.org/10.1016/j.cell.2021.01.053
State	Published - 1 Apr 2021
Externally published	Yes

Keywords

B cell receptor sequencing
COVID-19
SARS-CoV-2
T cell receptor sequencing
cell-cell interaction
cytokine storm
host cell range
ligand-receptor interaction
single-cell RNA-seq
single-cell transcriptomics

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10.1016/j.cell.2021.01.053

Cite this

@article{4cffae3d375744e4b21162a0a68ff799,

title = "COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas",

abstract = "Analysis of the immune landscape in the lung and peripheral blood of COVID patients across different regions in China at the single-cell level documents the presence of viral RNAs in diverse cell types and highlights the potential contribution of megakaryocytes and monocyte subsets to cytokine storms.",

keywords = "B cell receptor sequencing, COVID-19, SARS-CoV-2, T cell receptor sequencing, cell-cell interaction, cytokine storm, host cell range, ligand-receptor interaction, single-cell RNA-seq, single-cell transcriptomics",

author = "Xianwen Ren and Wen Wen and Xiaoying Fan and Wenhong Hou and Bin Su and Pengfei Cai and Jiesheng Li and Yang Liu and Fei Tang and Fan Zhang and Yu Yang and Jiangping He and Wenji Ma and Jingjing He and Pingping Wang and Qiqi Cao and Fangjin Chen and Yuqing Chen and Xuelian Cheng and Guohong Deng and Xilong Deng and Wenyu Ding and Yingmei Feng and Rui Gan and Chuang Guo and Weiqiang Guo and Shuai He and Chen Jiang and Juanran Liang and Li, \{Yi min\} and Jun Lin and Yun Ling and Haofei Liu and Jianwei Liu and Nianping Liu and Liu, \{Shu Qiang\} and Meng Luo and Qiang Ma and Qibing Song and Wujianan Sun and Wang, \{Gao Xiang\} and Feng Wang and Ying Wang and Xiaofeng Wen and Qian Wu and Gang Xu and Xiaowei Xie and Xinxin Xiong and Xudong Xing and Hao Xu and Chonghai Yin and Dongdong Yu and Kezhuo Yu and Jin Yuan and Biao Zhang and Peipei Zhang and Tong Zhang and Jincun Zhao and Peidong Zhao and Jianfeng Zhou and Wei Zhou and Sujuan Zhong and Xiaosong Zhong and Shuye Zhang and Lin Zhu and Ping Zhu and Bin Zou and Jiahua Zou and Zengtao Zuo and Fan Bai and Xi Huang and Penghui Zhou and Qinghua Jiang and Zhiwei Huang and Bei, \{Jin Xin\} and Lai Wei and Bian, \{Xiu Wu\} and Xindong Liu and Tao Cheng and Xiangpan Li and Pingsen Zhao and Wang, \{Fu Sheng\} and Hongyang Wang and Bing Su and Zheng Zhang and Kun Qu and Xiaoqun Wang and Jiekai Chen and Ronghua Jin and Zemin Zhang",

note = "Publisher Copyright: {\textcopyright} 2021 Elsevier Inc.",

year = "2021",

month = apr,

day = "1",

doi = "10.1016/j.cell.2021.01.053",

language = "英语",

volume = "184",

pages = "1895--1913.e19",

journal = "Cell",

issn = "0092-8674",

publisher = "Elsevier B.V.",

number = "7",

}

Ren, X, Wen, W, Fan, X, Hou, W, Su, B, Cai, P, Li, J, Liu, Y, Tang, F, Zhang, F, Yang, Y, He, J, Ma, W, He, J, Wang, P, Cao, Q, Chen, F, Chen, Y, Cheng, X, Deng, G, Deng, X, Ding, W, Feng, Y, Gan, R, Guo, C, Guo, W, He, S, Jiang, C, Liang, J, Li, YM, Lin, J, Ling, Y, Liu, H, Liu, J, Liu, N, Liu, SQ, Luo, M, Ma, Q, Song, Q, Sun, W, Wang, GX, Wang, F, Wang, Y, Wen, X, Wu, Q, Xu, G, Xie, X, Xiong, X, Xing, X, Xu, H, Yin, C, Yu, D, Yu, K, Yuan, J, Zhang, B, Zhang, P, Zhang, T, Zhao, J, Zhao, P, Zhou, J, Zhou, W, Zhong, S, Zhong, X, Zhang, S, Zhu, L, Zhu, P, Zou, B, Zou, J, Zuo, Z, Bai, F, Huang, X, Zhou, P, Jiang, Q , Huang, Z, Bei, JX, Wei, L, Bian, XW, Liu, X, Cheng, T, Li, X, Zhao, P, Wang, FS, Wang, H, Su, B, Zhang, Z, Qu, K, Wang, X, Chen, J, Jin, R & Zhang, Z 2021, 'COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas', Cell, vol. 184, no. 7, pp. 1895-1913.e19. https://doi.org/10.1016/j.cell.2021.01.053

TY - JOUR

T1 - COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

AU - Ren, Xianwen

AU - Wen, Wen

AU - Fan, Xiaoying

AU - Hou, Wenhong

AU - Su, Bin

AU - Cai, Pengfei

AU - Li, Jiesheng

AU - Liu, Yang

AU - Tang, Fei

AU - Zhang, Fan

AU - Yang, Yu

AU - He, Jiangping

AU - Ma, Wenji

AU - He, Jingjing

AU - Wang, Pingping

AU - Cao, Qiqi

AU - Chen, Fangjin

AU - Chen, Yuqing

AU - Cheng, Xuelian

AU - Deng, Guohong

AU - Deng, Xilong

AU - Ding, Wenyu

AU - Feng, Yingmei

AU - Gan, Rui

AU - Guo, Chuang

AU - Guo, Weiqiang

AU - He, Shuai

AU - Jiang, Chen

AU - Liang, Juanran

AU - Li, Yi min

AU - Lin, Jun

AU - Ling, Yun

AU - Liu, Haofei

AU - Liu, Jianwei

AU - Liu, Nianping

AU - Liu, Shu Qiang

AU - Luo, Meng

AU - Ma, Qiang

AU - Song, Qibing

AU - Sun, Wujianan

AU - Wang, Gao Xiang

AU - Wang, Feng

AU - Wang, Ying

AU - Wen, Xiaofeng

AU - Wu, Qian

AU - Xu, Gang

AU - Xie, Xiaowei

AU - Xiong, Xinxin

AU - Xing, Xudong

AU - Xu, Hao

AU - Yin, Chonghai

AU - Yu, Dongdong

AU - Yu, Kezhuo

AU - Yuan, Jin

AU - Zhang, Biao

AU - Zhang, Peipei

AU - Zhang, Tong

AU - Zhao, Jincun

AU - Zhao, Peidong

AU - Zhou, Jianfeng

AU - Zhou, Wei

AU - Zhong, Sujuan

AU - Zhong, Xiaosong

AU - Zhang, Shuye

AU - Zhu, Lin

AU - Zhu, Ping

AU - Zou, Bin

AU - Zou, Jiahua

AU - Zuo, Zengtao

AU - Bai, Fan

AU - Huang, Xi

AU - Zhou, Penghui

AU - Jiang, Qinghua

AU - Huang, Zhiwei

AU - Bei, Jin Xin

AU - Wei, Lai

AU - Bian, Xiu Wu

AU - Liu, Xindong

AU - Cheng, Tao

AU - Li, Xiangpan

AU - Zhao, Pingsen

AU - Wang, Fu Sheng

AU - Wang, Hongyang

AU - Su, Bing

AU - Zhang, Zheng

AU - Qu, Kun

AU - Wang, Xiaoqun

AU - Chen, Jiekai

AU - Jin, Ronghua

AU - Zhang, Zemin

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Analysis of the immune landscape in the lung and peripheral blood of COVID patients across different regions in China at the single-cell level documents the presence of viral RNAs in diverse cell types and highlights the potential contribution of megakaryocytes and monocyte subsets to cytokine storms.

AB - Analysis of the immune landscape in the lung and peripheral blood of COVID patients across different regions in China at the single-cell level documents the presence of viral RNAs in diverse cell types and highlights the potential contribution of megakaryocytes and monocyte subsets to cytokine storms.

KW - B cell receptor sequencing

KW - COVID-19

KW - SARS-CoV-2

KW - T cell receptor sequencing

KW - cell-cell interaction

KW - cytokine storm

KW - host cell range

KW - ligand-receptor interaction

KW - single-cell RNA-seq

KW - single-cell transcriptomics

UR - https://www.scopus.com/pages/publications/85101887279

U2 - 10.1016/j.cell.2021.01.053

DO - 10.1016/j.cell.2021.01.053

M3 - 文章

C2 - 33657410

AN - SCOPUS:85101887279

SN - 0092-8674

VL - 184

SP - 1895-1913.e19

JO - Cell

JF - Cell

IS - 7

ER -

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Abstract

Keywords

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