Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents

Peng Ren; Lucas Alexandre Stern; Xile Hu

doi:10.1002/anie.201204275

Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents

Peng Ren
, Lucas Alexandre Stern
, Xile Hu^*

^*Corresponding author for this work

Swiss Federal Institute of Technology Lausanne

Research output: Contribution to journal › Article › peer-review

107 Scopus citations

Abstract

Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance.

Original language	English
Pages (from-to)	9110-9113
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	51
Issue number	36
DOIs	https://doi.org/10.1002/anie.201204275
State	Published - 3 Sep 2012
Externally published	Yes

Keywords

Grignard reaction
alkylation
copper
cross-coupling
homogeneous catalysis

Access to Document

10.1002/anie.201204275

Cite this

@article{65493844417a4404bec29cd395cc3ddd,

title = "Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents",

abstract = "Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance.",

keywords = "Grignard reaction, alkylation, copper, cross-coupling, homogeneous catalysis",

author = "Peng Ren and Stern, \{Lucas Alexandre\} and Xile Hu",

year = "2012",

month = sep,

day = "3",

doi = "10.1002/anie.201204275",

language = "英语",

volume = "51",

pages = "9110--9113",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "36",

}

TY - JOUR

T1 - Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents

AU - Ren, Peng

AU - Stern, Lucas Alexandre

AU - Hu, Xile

PY - 2012/9/3

Y1 - 2012/9/3

N2 - Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance.

AB - Added value: A copper-based method is highly efficient for the cross-coupling of alkyl electrophiles with secondary and tertiary alkyl Grignard reagents. The method is distinguished by its broad substrate scope and high functional group tolerance.

KW - Grignard reaction

KW - alkylation

KW - copper

KW - cross-coupling

KW - homogeneous catalysis

UR - https://www.scopus.com/pages/publications/84865838299

U2 - 10.1002/anie.201204275

DO - 10.1002/anie.201204275

M3 - 文章

AN - SCOPUS:84865838299

SN - 1433-7851

VL - 51

SP - 9110

EP - 9113

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 36

ER -

Copper-catalyzed cross-coupling of functionalized alkyl halides and tosylates with secondary and tertiary alkyl Grignard reagents

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this