Conformational changes of high-molecular-weight DNA upon binding to noble metal nanoparticles in solution

N. A. Kasyanenko; A. V. Baryshev; V. M. Bakulev

doi:10.1007/s11172-021-3275-3

Conformational changes of high-molecular-weight DNA upon binding to noble metal nanoparticles in solution

N. A. Kasyanenko^*
, A. V. Baryshev
, V. M. Bakulev

^*Corresponding author for this work

St. Petersburg State University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Changes in the secondary and tertiary structure of DNA upon binding to silver, gold, and palladium nanoparticles (NPs) in solution were studied using UV spectroscopy, viscometry, dynamic light scattering, flow birefringence, and atomic force microscopy. A method for preparation of NP bioconjugates with DNA was developed. The enhancement of optical anisotropy of the macromolecule upon its contacts with metal NPs was detected. The effect of the formed structures on the persistence length of DNA and on the volume effects in the system was analyzed. A mechanism of NP formation upon the reduction of DNA-bound metal ions was proposed.

Original language	English
Pages (from-to)	1718-1724
Number of pages	7
Journal	Russian Chemical Bulletin
Volume	70
Issue number	9
DOIs	https://doi.org/10.1007/s11172-021-3275-3
State	Published - Sep 2021
Externally published	Yes

Keywords

DNA with nanoparticles
gold, silver, and palladium nanoparticles
persistence length of DNA, increase in optical anisotropy

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10.1007/s11172-021-3275-3

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title = "Conformational changes of high-molecular-weight DNA upon binding to noble metal nanoparticles in solution",

abstract = "Changes in the secondary and tertiary structure of DNA upon binding to silver, gold, and palladium nanoparticles (NPs) in solution were studied using UV spectroscopy, viscometry, dynamic light scattering, flow birefringence, and atomic force microscopy. A method for preparation of NP bioconjugates with DNA was developed. The enhancement of optical anisotropy of the macromolecule upon its contacts with metal NPs was detected. The effect of the formed structures on the persistence length of DNA and on the volume effects in the system was analyzed. A mechanism of NP formation upon the reduction of DNA-bound metal ions was proposed.",

keywords = "DNA with nanoparticles, gold, silver, and palladium nanoparticles, persistence length of DNA, increase in optical anisotropy",

author = "Kasyanenko, \{N. A.\} and Baryshev, \{A. V.\} and Bakulev, \{V. M.\}",

note = "Publisher Copyright: {\textcopyright} 2021, Springer Science+Business Media LLC.",

year = "2021",

month = sep,

doi = "10.1007/s11172-021-3275-3",

language = "英语",

volume = "70",

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journal = "Russian Chemical Bulletin",

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T1 - Conformational changes of high-molecular-weight DNA upon binding to noble metal nanoparticles in solution

AU - Kasyanenko, N. A.

AU - Baryshev, A. V.

AU - Bakulev, V. M.

PY - 2021/9

Y1 - 2021/9

N2 - Changes in the secondary and tertiary structure of DNA upon binding to silver, gold, and palladium nanoparticles (NPs) in solution were studied using UV spectroscopy, viscometry, dynamic light scattering, flow birefringence, and atomic force microscopy. A method for preparation of NP bioconjugates with DNA was developed. The enhancement of optical anisotropy of the macromolecule upon its contacts with metal NPs was detected. The effect of the formed structures on the persistence length of DNA and on the volume effects in the system was analyzed. A mechanism of NP formation upon the reduction of DNA-bound metal ions was proposed.

AB - Changes in the secondary and tertiary structure of DNA upon binding to silver, gold, and palladium nanoparticles (NPs) in solution were studied using UV spectroscopy, viscometry, dynamic light scattering, flow birefringence, and atomic force microscopy. A method for preparation of NP bioconjugates with DNA was developed. The enhancement of optical anisotropy of the macromolecule upon its contacts with metal NPs was detected. The effect of the formed structures on the persistence length of DNA and on the volume effects in the system was analyzed. A mechanism of NP formation upon the reduction of DNA-bound metal ions was proposed.

KW - DNA with nanoparticles

KW - gold, silver, and palladium nanoparticles

KW - persistence length of DNA, increase in optical anisotropy

UR - https://www.scopus.com/pages/publications/85118203917

U2 - 10.1007/s11172-021-3275-3

DO - 10.1007/s11172-021-3275-3

M3 - 文章

AN - SCOPUS:85118203917

SN - 1066-5285

VL - 70

SP - 1718

EP - 1724

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

IS - 9

ER -

Conformational changes of high-molecular-weight DNA upon binding to noble metal nanoparticles in solution

Abstract

Keywords

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