Computational studies of DNA sequencing with solid-state nanopores: Key issues and future prospects

Lijun Liang; Qi Wang; Hans Ågren; Yaoquan Tu

doi:10.3389/fchem.2014.00005

Computational studies of DNA sequencing with solid-state nanopores: Key issues and future prospects

Lijun Liang
, Qi Wang
, Hans Ågren
, Yaoquan Tu^*

^*Corresponding author for this work

KTH Royal Institute of Technology
Zhejiang University

Research output: Contribution to journal › Short survey › peer-review

11 Scopus citations

Abstract

Owing to the potential use for real personalized genome sequencing, DNA sequencing with solid-state nanopores has been investigated intensively in recent time. However, the area still confronts problems and challenges. In this work, we present a brief overview of computational studies of key issues in DNA sequencing with solid-state nanopores by addressing the progress made in the last few years. We also highlight future challenges and prospects for DNA sequencing using this technology.

Original language	English
Article number	5
Journal	Frontiers in Chemistry
Volume	2
Issue number	FEB
DOIs	https://doi.org/10.3389/fchem.2014.00005
State	Published - 2014
Externally published	Yes

Keywords

Bio-nanotechnology
Computer modeling
DNA sequencing
Graphene nanopore
Molecular simulation
Solid-state nanopore
Theory

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10.3389/fchem.2014.00005

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abstract = "Owing to the potential use for real personalized genome sequencing, DNA sequencing with solid-state nanopores has been investigated intensively in recent time. However, the area still confronts problems and challenges. In this work, we present a brief overview of computational studies of key issues in DNA sequencing with solid-state nanopores by addressing the progress made in the last few years. We also highlight future challenges and prospects for DNA sequencing using this technology.",

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AU - Liang, Lijun

AU - Wang, Qi

AU - Ågren, Hans

AU - Tu, Yaoquan

PY - 2014

Y1 - 2014

N2 - Owing to the potential use for real personalized genome sequencing, DNA sequencing with solid-state nanopores has been investigated intensively in recent time. However, the area still confronts problems and challenges. In this work, we present a brief overview of computational studies of key issues in DNA sequencing with solid-state nanopores by addressing the progress made in the last few years. We also highlight future challenges and prospects for DNA sequencing using this technology.

AB - Owing to the potential use for real personalized genome sequencing, DNA sequencing with solid-state nanopores has been investigated intensively in recent time. However, the area still confronts problems and challenges. In this work, we present a brief overview of computational studies of key issues in DNA sequencing with solid-state nanopores by addressing the progress made in the last few years. We also highlight future challenges and prospects for DNA sequencing using this technology.

KW - Bio-nanotechnology

KW - Computer modeling

KW - DNA sequencing

KW - Graphene nanopore

KW - Molecular simulation

KW - Solid-state nanopore

KW - Theory

UR - https://www.scopus.com/pages/publications/84987641951

U2 - 10.3389/fchem.2014.00005

DO - 10.3389/fchem.2014.00005

M3 - 短篇评述

AN - SCOPUS:84987641951

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VL - 2

JO - Frontiers in Chemistry

JF - Frontiers in Chemistry

IS - FEB

M1 - 5

ER -

Computational studies of DNA sequencing with solid-state nanopores: Key issues and future prospects

Abstract

Keywords

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