Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

G. S. Tsebrikova; R. T. Barsamian; V. P. Solov´ev; Z. A. Kudryashova; V. E. Baulin; Y. J. Wang; A. Yu Tsivadze

doi:10.1007/s11172-018-2352-8

Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

G. S. Tsebrikova^*
, R. T. Barsamian
, V. P. Solov´ev
, Z. A. Kudryashova
, V. E. Baulin
, Y. J. Wang
, A. Yu Tsivadze

^*Corresponding author for this work

Russian Academy of Sciences
MIREA - Russian Technological University
Harbin Institute of Technology

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H₈L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga³⁺ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga³⁺ complex with the fully deprotonated DOTMP ligand, lg K_ML equal to 27.8, is higher than the corresponding constant for the Ga³⁺ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga³⁺ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.

Original language	English
Pages (from-to)	2184-2187
Number of pages	4
Journal	Russian Chemical Bulletin
Volume	67
Issue number	12
DOIs	https://doi.org/10.1007/s11172-018-2352-8
State	Published - 1 Dec 2018
Externally published	Yes

Keywords

1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)
dissociation constant of acid
gallium(III)
potentiometric titration
radiopharmaceuticals
stability constant of metal-ligand complex

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10.1007/s11172-018-2352-8

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@article{35037efa165f4a5496a3cbf39bfb561b,

title = "Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)",

abstract = "Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.",

keywords = "1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid), dissociation constant of acid, gallium(III), potentiometric titration, radiopharmaceuticals, stability constant of metal-ligand complex",

author = "Tsebrikova, \{G. S.\} and Barsamian, \{R. T.\} and Solov´ev, \{V. P.\} and Kudryashova, \{Z. A.\} and Baulin, \{V. E.\} and Wang, \{Y. J.\} and Tsivadze, \{A. Yu\}",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2018",

month = dec,

day = "1",

doi = "10.1007/s11172-018-2352-8",

language = "英语",

volume = "67",

pages = "2184--2187",

journal = "Russian Chemical Bulletin",

issn = "1066-5285",

publisher = "Springer New York",

number = "12",

}

TY - JOUR

T1 - Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

AU - Tsebrikova, G. S.

AU - Barsamian, R. T.

AU - Solov´ev, V. P.

AU - Kudryashova, Z. A.

AU - Baulin, V. E.

AU - Wang, Y. J.

AU - Tsivadze, A. Yu

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.

AB - Eight dissociation constants of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis (methylene phosphonic acid) (DOTMP, H8L) were determined for the first time by potentiometric titration in water using the CHEMEQUI program. The stability constants of Ga3+ complexes with deprotonated forms of DOTMP were determined. The stability constant of the Ga3+ complex with the fully deprotonated DOTMP ligand, lg KML equal to 27.8, is higher than the corresponding constant for the Ga3+ complex with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA), the ligand most widely used in radiopharmacy; it is also higher than the constant for the Ga3+ complex with plasma protein transferrin, which makes the DOTMP ligand very promising for the use in radiopharmacy.

KW - 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

KW - dissociation constant of acid

KW - gallium(III)

KW - potentiometric titration

KW - radiopharmaceuticals

KW - stability constant of metal-ligand complex

UR - https://www.scopus.com/pages/publications/85061025490

U2 - 10.1007/s11172-018-2352-8

DO - 10.1007/s11172-018-2352-8

M3 - 文章

AN - SCOPUS:85061025490

SN - 1066-5285

VL - 67

SP - 2184

EP - 2187

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

IS - 12

ER -

Complexation of gallium(III) nitrate with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonic acid)

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