@inbook{68da7bc0dc7a4438862f9baf67e49c5d,
title = "Challenges in bio-fabrication of organoid cultures",
abstract = "Three-dimensional (3D) organoids have shown advantages in cell culture over traditional two-dimensional (2D) culture, and have great potential in various applications of tissue engineering. However, there are limitations in current organoid fabrication technologies, such as uncontrolled size, poor reproductively, and inadequate complexity of organoids. In this chapter, we present the existing techniques and discuss the major challenges for 3D organoid biofabrication. Future perspectives on organoid bioprinting are also discussed, where bioprinting technologies are expected to make a major contribution in organoid fabrication, such as realizing mass production and constructing complex heterotypic tissues, and thus further advance the translational application of organoids in tissue engineering and regenerative medicine as well drug testing and pharmaceutics.",
keywords = "3D culture, Bioprinting, Organoids, Regenerative medicine, Tissue engineering",
author = "Weijie Peng and Pallab Datta and Yang Wu and Madhuri Dey and Bugra Ayan and Amer Dababneh and Ozbolat, \{Ibrahim T.\}",
note = "Publisher Copyright: {\textcopyright} Springer International Publishing AG, part of Springer Nature 2018.",
year = "2018",
doi = "10.1007/5584\_2018\_216",
language = "英语",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer New York LLC",
pages = "53--71",
booktitle = "Advances in Experimental Medicine and Biology",
}