Cancer Cell Membrane-Camouflaged Micromotor

A type of cancer cell membrane-camouflaged and gold nanoshell-functionalized CaCO₃ (CGNCaCO₃) micromotor and its ability to modulate immune activity are described. The process used to fabricate these micromotors includes the synthesis of CaCO₃ particles, the functionalization of the gold nanoshell, and the fusion of cancer cell membrane vesicles onto the gold nanoshell-functionalized CaCO₃ (GNCaCO₃) particles. Due to the benefit of the homotypic binding of the cancer cell membrane, the autonomous movement of CGNCaCO₃ micromotors results in their substantial accumulation on cancer cells. The subcutaneous injection of CGNCaCO₃ micromotors enhances their immune activity by camouflaging cancer cells. Such CGNCaCO₃ micromotors inherit the biological features of natural cancer cells and are able to facilitate a broad range of antigenic and biological processes that common synthetic motors cannot achieve, and thus, these micromotors hold considerable promise for a number of practical biomedical uses.