BLAT2DOLite: An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases

Liang Cheng; Shuo Zhang; Yang Hu

doi:10.1371/journal.pone.0157274

BLAT2DOLite: An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases

Liang Cheng^*
, Shuo Zhang
, Yang Hu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The significantly related diseases of sequences could play an important role in understanding the functions of these sequences. In this paper, we introduced BLAT2DOLite, an online system for annotating human genes and diseases and identifying the significant relationships between sequences and diseases. Currently, BLAT2DOLite integrates Entrez Gene database and Disease Ontology Lite (DOLite), which contain loci of gene and relationships between genes and diseases. It utilizes hypergeometric test to calculate P-values between genes and diseases of DOLite. The system can be accessed from: http://123.59.132. 21:8080/BLAT2DOLite. The corresponding web service is described in: http://123.59.132. 21:8080/BLAT2DOLite/BLAT2DOLiteIDMappingPort?wsdl.

Original language	English
Article number	e0157274
Journal	PLOS ONE
Volume	11
Issue number	6
DOIs	https://doi.org/10.1371/journal.pone.0157274
State	Published - Jun 2016
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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title = "BLAT2DOLite: An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases",

abstract = "The significantly related diseases of sequences could play an important role in understanding the functions of these sequences. In this paper, we introduced BLAT2DOLite, an online system for annotating human genes and diseases and identifying the significant relationships between sequences and diseases. Currently, BLAT2DOLite integrates Entrez Gene database and Disease Ontology Lite (DOLite), which contain loci of gene and relationships between genes and diseases. It utilizes hypergeometric test to calculate P-values between genes and diseases of DOLite. The system can be accessed from: http://123.59.132. 21:8080/BLAT2DOLite. The corresponding web service is described in: http://123.59.132. 21:8080/BLAT2DOLite/BLAT2DOLiteIDMappingPort?wsdl.",

author = "Liang Cheng and Shuo Zhang and Yang Hu",

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T2 - An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases

AU - Cheng, Liang

AU - Zhang, Shuo

AU - Hu, Yang

N1 - Publisher Copyright: © 2016 Cheng et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

PY - 2016/6

Y1 - 2016/6

N2 - The significantly related diseases of sequences could play an important role in understanding the functions of these sequences. In this paper, we introduced BLAT2DOLite, an online system for annotating human genes and diseases and identifying the significant relationships between sequences and diseases. Currently, BLAT2DOLite integrates Entrez Gene database and Disease Ontology Lite (DOLite), which contain loci of gene and relationships between genes and diseases. It utilizes hypergeometric test to calculate P-values between genes and diseases of DOLite. The system can be accessed from: http://123.59.132. 21:8080/BLAT2DOLite. The corresponding web service is described in: http://123.59.132. 21:8080/BLAT2DOLite/BLAT2DOLiteIDMappingPort?wsdl.

AB - The significantly related diseases of sequences could play an important role in understanding the functions of these sequences. In this paper, we introduced BLAT2DOLite, an online system for annotating human genes and diseases and identifying the significant relationships between sequences and diseases. Currently, BLAT2DOLite integrates Entrez Gene database and Disease Ontology Lite (DOLite), which contain loci of gene and relationships between genes and diseases. It utilizes hypergeometric test to calculate P-values between genes and diseases of DOLite. The system can be accessed from: http://123.59.132. 21:8080/BLAT2DOLite. The corresponding web service is described in: http://123.59.132. 21:8080/BLAT2DOLite/BLAT2DOLiteIDMappingPort?wsdl.

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BLAT2DOLite: An Online System for Identifying Significant Relationships between Genetic Sequences and Diseases

Abstract

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