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Biotic communities inspired proteinosome-based aggregation for enhancing utilization rate of enzyme

  • School of Chemistry and Chemical Engineering, Harbin Institute of Technology

Research output: Contribution to journalArticlepeer-review

Abstract

Compared with the individuals, the collective behavior of biotic communities could show certain superior characteristics. Inspired by this idea and based on the conjugation between phenylboronic acid-grafted mesoporous silica nanoparticles and the polysaccharide functionalized membrane of proteinosomes, a type of proteinosomes-based aggregations was constructed. We demonstrated the emergent characteristics of proteinosomes aggregations including accelerated settling velocity and population surviving by sacrificing outside members for the inside. Moreover, this kind of “hand in hand” architecture provided the proteinosomes aggregations with the characteristic of resistance to the negative pressure phagocytosis of micropipette, as well as enhancing utilization rate of the encapsulated enzymes. Overall, it is anticipated that the construction and application of proteinosomes aggregations could contribute to advance the functionality of life-like assembled biomaterial in another way.

Original languageEnglish
Pages (from-to)456-465
Number of pages10
JournalJournal of Colloid and Interface Science
Volume635
DOIs
StatePublished - Apr 2023
Externally publishedYes

Keywords

  • Biomimetic material
  • Collective behavior
  • Enzyme immobilization
  • Proteinosome aggregations

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