TY - GEN
T1 - Biomechanical analysis of yeast cell based a piezoresistive cantilever sensor
AU - Xu, Wenkui
AU - Chen, Liguo
AU - Huang, Haibo
AU - Zhang, Leilei
AU - Li, Xiangpeng
AU - Li, Yadi
AU - Sun, Lining
N1 - Publisher Copyright:
© 2016 IEEE.
PY - 2016/12/14
Y1 - 2016/12/14
N2 - The biomechanical properties (Young's Modulus, stiffness, adhesion force) is important for the cell micro/nano manipulation. In this article, a piezoresistive cantilever sensor is suitable for measuring quantitatively Young's Modulus of a single yeast cell because of some advantage of high sensitivity, dynamic response, simple structure, low cost. For calibrating a piezoresistive cantilever's elastic coefficient, it is carried out through the setup designed. Between the force, the cantilever tip deflection and the output voltage follow a good linear relationship. Analyzing the recorded force curves by applying Hertz-Sneddon model allows the extraction of cell mechanical properties Young's Modulus. Young's Modulus is realized for measuring single yeast cell, yielding young's modulus values of 2.9 ± 2.2Mpa. The result indicates that Young's Modulus measured both by a piezoresistive cantilever and AFM precise can be in good consistency of order of magnitude. Investigations aiming a description of micro/nanoforce measuring of the piezoresistive cantilever sensor are conducted in micro/nano manipulation.
AB - The biomechanical properties (Young's Modulus, stiffness, adhesion force) is important for the cell micro/nano manipulation. In this article, a piezoresistive cantilever sensor is suitable for measuring quantitatively Young's Modulus of a single yeast cell because of some advantage of high sensitivity, dynamic response, simple structure, low cost. For calibrating a piezoresistive cantilever's elastic coefficient, it is carried out through the setup designed. Between the force, the cantilever tip deflection and the output voltage follow a good linear relationship. Analyzing the recorded force curves by applying Hertz-Sneddon model allows the extraction of cell mechanical properties Young's Modulus. Young's Modulus is realized for measuring single yeast cell, yielding young's modulus values of 2.9 ± 2.2Mpa. The result indicates that Young's Modulus measured both by a piezoresistive cantilever and AFM precise can be in good consistency of order of magnitude. Investigations aiming a description of micro/nanoforce measuring of the piezoresistive cantilever sensor are conducted in micro/nano manipulation.
UR - https://www.scopus.com/pages/publications/85010053607
U2 - 10.1109/RCAR.2016.7784058
DO - 10.1109/RCAR.2016.7784058
M3 - 会议稿件
AN - SCOPUS:85010053607
T3 - 2016 IEEE International Conference on Real-Time Computing and Robotics, RCAR 2016
SP - 379
EP - 384
BT - 2016 IEEE International Conference on Real-Time Computing and Robotics, RCAR 2016
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2016 IEEE International Conference on Real-Time Computing and Robotics, RCAR 2016
Y2 - 6 June 2016 through 9 June 2016
ER -