Bioactivity of a new staurosporine derivative from a marine Streptomyces sp. strain M518

Shaojie Wu; Fuchao Li; Song Qin; Fangqing Zhao; Yanhua Hou; Serge Fotso; Heinz H. Fiebig; Hartmurt Laatsch

Bioactivity of a new staurosporine derivative from a marine Streptomyces sp. strain M518

Shaojie Wu^*
, Fuchao Li
, Song Qin
, Fangqing Zhao
, Yanhua Hou
, Serge Fotso
, Heinz H. Fiebig
, Hartmurt Laatsch

^*Corresponding author for this work

CAS - Institute of Oceanology
University of Chinese Academy of Sciences
University of Göttingen
Charles River Laboratories

Research output: Contribution to journal › Article › peer-review

Abstract

A new staurosporine derivative, N-carboxamido-staurosporine (1c), was isolated from a marine actinomycetes strain M518, together with the known compounds N-formyl-staurosporine (1b) and staurosporine (1a). Anticancer activities against 37 human cancer cell lines of 1b and 1c and antimicrobial activities against 9 microorganisms of 1a, 1b and 1c were tested. The results showed that 1c exhibited stronger anticancer bioactivity than 1b. The average IC₅₀, IC₇₀ and IC₉₀ of 1c against 37 cell lines were 0.016, 0.171 and 2.352 μg·mL^-1 respectively. Compounds 1a, 1b and 1c also exhibited good inhibitory activity against microalgae. Phylogenetic analysis based on 16S rRNA gene indicated that strain M518 belongs to Streptomyces genus.

Original language	English
Pages (from-to)	874-879
Number of pages	6
Journal	Gaojishu Tongxin/Chinese High Technology Letters
Volume	17
Issue number	8
State	Published - Aug 2007
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being
SDG 14 Life Below Water

Keywords

16S rRNA
Bioactivity
Marine Streptomyces
Staurosporine

Cite this

@article{014bf4952bf54dc79c851036f650a667,

title = "Bioactivity of a new staurosporine derivative from a marine Streptomyces sp. strain M518",

abstract = "A new staurosporine derivative, N-carboxamido-staurosporine (1c), was isolated from a marine actinomycetes strain M518, together with the known compounds N-formyl-staurosporine (1b) and staurosporine (1a). Anticancer activities against 37 human cancer cell lines of 1b and 1c and antimicrobial activities against 9 microorganisms of 1a, 1b and 1c were tested. The results showed that 1c exhibited stronger anticancer bioactivity than 1b. The average IC50, IC70 and IC90 of 1c against 37 cell lines were 0.016, 0.171 and 2.352 μg·mL-1 respectively. Compounds 1a, 1b and 1c also exhibited good inhibitory activity against microalgae. Phylogenetic analysis based on 16S rRNA gene indicated that strain M518 belongs to Streptomyces genus.",

keywords = "16S rRNA, Bioactivity, Marine Streptomyces, Staurosporine",

author = "Shaojie Wu and Fuchao Li and Song Qin and Fangqing Zhao and Yanhua Hou and Serge Fotso and Fiebig, \{Heinz H.\} and Hartmurt Laatsch",

year = "2007",

month = aug,

language = "英语",

volume = "17",

pages = "874--879",

journal = "Gaojishu Tongxin/Chinese High Technology Letters",

issn = "1002-0470",

publisher = "Institute of Scientific and Technical Information of China ",

number = "8",

}

TY - JOUR

T1 - Bioactivity of a new staurosporine derivative from a marine Streptomyces sp. strain M518

AU - Wu, Shaojie

AU - Li, Fuchao

AU - Qin, Song

AU - Zhao, Fangqing

AU - Hou, Yanhua

AU - Fotso, Serge

AU - Fiebig, Heinz H.

AU - Laatsch, Hartmurt

PY - 2007/8

Y1 - 2007/8

N2 - A new staurosporine derivative, N-carboxamido-staurosporine (1c), was isolated from a marine actinomycetes strain M518, together with the known compounds N-formyl-staurosporine (1b) and staurosporine (1a). Anticancer activities against 37 human cancer cell lines of 1b and 1c and antimicrobial activities against 9 microorganisms of 1a, 1b and 1c were tested. The results showed that 1c exhibited stronger anticancer bioactivity than 1b. The average IC50, IC70 and IC90 of 1c against 37 cell lines were 0.016, 0.171 and 2.352 μg·mL-1 respectively. Compounds 1a, 1b and 1c also exhibited good inhibitory activity against microalgae. Phylogenetic analysis based on 16S rRNA gene indicated that strain M518 belongs to Streptomyces genus.

AB - A new staurosporine derivative, N-carboxamido-staurosporine (1c), was isolated from a marine actinomycetes strain M518, together with the known compounds N-formyl-staurosporine (1b) and staurosporine (1a). Anticancer activities against 37 human cancer cell lines of 1b and 1c and antimicrobial activities against 9 microorganisms of 1a, 1b and 1c were tested. The results showed that 1c exhibited stronger anticancer bioactivity than 1b. The average IC50, IC70 and IC90 of 1c against 37 cell lines were 0.016, 0.171 and 2.352 μg·mL-1 respectively. Compounds 1a, 1b and 1c also exhibited good inhibitory activity against microalgae. Phylogenetic analysis based on 16S rRNA gene indicated that strain M518 belongs to Streptomyces genus.

KW - 16S rRNA

KW - Bioactivity

KW - Marine Streptomyces

KW - Staurosporine

UR - https://www.scopus.com/pages/publications/34548509665

M3 - 文章

AN - SCOPUS:34548509665

SN - 1002-0470

VL - 17

SP - 874

EP - 879

JO - Gaojishu Tongxin/Chinese High Technology Letters

JF - Gaojishu Tongxin/Chinese High Technology Letters

IS - 8

ER -

Bioactivity of a new staurosporine derivative from a marine Streptomyces sp. strain M518

Abstract

UN SDGs

Keywords

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