@inproceedings{e1f5920b1db04440ac5a92ad5b47f18b,
title = "Assessing estrogenic activities of selected endocrine disrupting chemicals and their combination effects",
abstract = "Yeast two-hybrid system was used to investigate the estrogenic activities of 13 kinds of representative endocrine disrupting chemicals (EDCs) and their combinary effects. Results show that the order of estrogenic potencies for these chemicals is: 17α-ethynylestradiol>diethylstilbestrol >17β-estradiol>estrone>estriol>branched p-nonylphenol>4-t-octylphenol>bisphenol A>diethyl phthalate>4-n-nonylphenol>di-(2-ethylhexyl) phthalate>dibutyl phthalate>dimethyl phthalate. The mixture effects of multiple EDCs were compared to those obtained from individual chemicals, using the model of concentration addition. Results reveal that the estrogenicities of multicomponent mixtures of more than three (including three) of EDCs follow antagonistic effects, while there is no definite conclusion for binary systems. The less than additive effects were also confirmed in the spiked experiments conducted in the extracts of real water samples.",
keywords = "Combination effect, Endocrine disrupting chemicals, Estrogenic activity, Yeast two-hybrid system",
author = "Shao, \{Xiao Ling\} and Zhong, \{Wen Qi\} and Ma, \{Xiao Yan\} and Ang Gao and Wu, \{Xiang Yang\} and Jun Ma",
year = "2013",
doi = "10.4028/www.scientific.net/AMR.765-767.2944",
language = "英语",
isbn = "9783037857984",
series = "Advanced Materials Research",
pages = "2944--2948",
booktitle = "Advanced Information and Computer Technology in Engineering and Manufacturing, Environmental Engineering",
note = "2013 International Conference on Advances in Materials Science and Manufacturing Technology, AMSMT 2013 ; Conference date: 18-05-2013 Through 19-05-2013",
}