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Analysis and numerical simulations of a reaction-diffusion model with fixed active bodies

  • School of Mathematics, Harbin Institute of Technology
  • Universite Claude Bernard Lyon 1

Research output: Contribution to journalArticlepeer-review

Abstract

We propose an interaction model for two substances (molecules) of concentrations f and g. The substance f is assumed to be involved in the growth process of g, and in contrast, the substance g inhibits the production of f. Our model is based on a reaction-diffusion system for the interaction of two considered substances (molecules). We analyze its well-posedness and perform a numerical scheme to simulate the behavior of the solutions. As an application, we investigate the role of Aβ-oligomers in the early stage of Alzheimer's disease propagation, more precisely for the impact of Aβ-oligomers in neuron impairment as studied in [M. Andrade-Restrepo et al., Modeling the spatial propagation of Aβoligomers in Alzheimer's disease, in CEMRACS 2018 - Numerical and Mathematical Modeling for Biological and Medical Applications: Deterministic, Probabilistic and Statistical Descriptions, Marseille, France, 2018, pp. 1-10].

Original languageEnglish
Pages (from-to)1339-1360
Number of pages22
JournalSIAM Journal on Applied Mathematics
Volume81
Issue number4
DOIs
StatePublished - 2021
Externally publishedYes

Keywords

  • Activationinhibition process
  • Alzheimer's disease modeling
  • Crank-Nicolson scheme
  • Reaction-diffusion
  • Well-posedness of solutions

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