An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2

Anakin C.S. Leung; Engui Zhao; Ryan T.K. Kwok; Jacky W.Y. Lam; Chris W.T. Leung; Haiqin Deng; Ben Zhong Tang

doi:10.1039/c6tb01734g

An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H₂O₂

Anakin C.S. Leung
, Engui Zhao
, Ryan T.K. Kwok
, Jacky W.Y. Lam
, Chris W.T. Leung
, Haiqin Deng
, Ben Zhong Tang^*

^*Corresponding author for this work

Hong Kong University of Science and Technology
South China University of Technology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

A bioprobe, TPE-Zn₂BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H₂O₂. TPE-Zn₂BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

Original language	English
Pages (from-to)	5510-5514
Number of pages	5
Journal	Journal of Materials Chemistry B
Volume	4
Issue number	33
DOIs	https://doi.org/10.1039/c6tb01734g
State	Published - 2016
Externally published	Yes

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title = "An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H2O2",

abstract = "A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.",

author = "Leung, \{Anakin C.S.\} and Engui Zhao and Kwok, \{Ryan T.K.\} and Lam, \{Jacky W.Y.\} and Leung, \{Chris W.T.\} and Haiqin Deng and Tang, \{Ben Zhong\}",

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year = "2016",

doi = "10.1039/c6tb01734g",

language = "英语",

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AU - Leung, Anakin C.S.

AU - Zhao, Engui

AU - Kwok, Ryan T.K.

AU - Lam, Jacky W.Y.

AU - Leung, Chris W.T.

AU - Deng, Haiqin

AU - Tang, Ben Zhong

PY - 2016

Y1 - 2016

N2 - A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

AB - A bioprobe, TPE-Zn2BDPA, with aggregation-induced emission characteristics was designed and synthesized to differentiate the early and late stages of apoptosis mediated by H2O2. TPE-Zn2BDPA does not respond to healthy cells, but it selectively lights up the membrane of apopotic cells in both stages with brighter fluorescence in the late apoptotic stage.

UR - https://www.scopus.com/pages/publications/85023158401

U2 - 10.1039/c6tb01734g

DO - 10.1039/c6tb01734g

M3 - 文章

AN - SCOPUS:85023158401

SN - 2050-750X

VL - 4

SP - 5510

EP - 5514

JO - Journal of Materials Chemistry B

JF - Journal of Materials Chemistry B

IS - 33

ER -

An AIE-based bioprobe for differentiating the early and late stages of apoptosis mediated by H₂O₂

Abstract

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