Aminated multiwalled carbon nanotubes/oxidized regenerated cellulose nanocomposites for haemostatic applications

Ali Nabipour Chakoli; Saeed Ahmadi; Jin Mei He; Yu Dong Huang

doi:10.1016/j.matpr.2018.04.176

Aminated multiwalled carbon nanotubes/oxidized regenerated cellulose nanocomposites for haemostatic applications

Ali Nabipour Chakoli^*
, Saeed Ahmadi
, Jin Mei He
, Yu Dong Huang

^*Corresponding author for this work

Research output: Contribution to journal › Conference article › peer-review

6 Scopus citations

Abstract

Commercial surgical absorbable hemostatic agents have been widely applied in various surgeries and played an important role on stopping the bleeding. The commercial Oxidized Regenerated Cellulose (ORC) has also shown several inherent disadvantages. To improve the hemostatic effect of ORC, it has been modified by incorporating aminated MWCNTs (MWCNT-NH₂). For modification of neat ORC, the MWCNT-NH₂s was reacted with neat ORC. The analytical results revealed a relatively strong interaction existed between aminated MWCNTs and the ORC macromolecules. The hydrophilicity test results revealed significant increment in water uptake of MWCNT-NH₂s/ORC composites with increasing the concentration of MWCNT-NH₂s in composites. The haemostatic evaluation of MWCNT-NH₂s/ORC composites on rabbits showed that the aminated MWCNTs increased the rate of blood stopping, decreasing the blood loosing from injured sites.

Original language	English
Pages (from-to)	15661-15666
Number of pages	6
Journal	Materials Today: Proceedings
Volume	5
Issue number	7
DOIs	https://doi.org/10.1016/j.matpr.2018.04.176
State	Published - 2018
Externally published	Yes
Event	2017 INN International Conference/Workshop on Nanotechnology and Nanomedicine, NTNM 2017 - Tehran, Iran, Islamic Republic of Duration: 2 May 2017 → 3 May 2017

Keywords

Cross linking
Functionalized Carbon Nanotubes
Hemostatic effect
Oxidized Regenerated Cellulose

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10.1016/j.matpr.2018.04.176

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@article{6fae609ebb714cbd83011669a3a07a4d,

title = "Aminated multiwalled carbon nanotubes/oxidized regenerated cellulose nanocomposites for haemostatic applications",

abstract = "Commercial surgical absorbable hemostatic agents have been widely applied in various surgeries and played an important role on stopping the bleeding. The commercial Oxidized Regenerated Cellulose (ORC) has also shown several inherent disadvantages. To improve the hemostatic effect of ORC, it has been modified by incorporating aminated MWCNTs (MWCNT-NH2). For modification of neat ORC, the MWCNT-NH2s was reacted with neat ORC. The analytical results revealed a relatively strong interaction existed between aminated MWCNTs and the ORC macromolecules. The hydrophilicity test results revealed significant increment in water uptake of MWCNT-NH2s/ORC composites with increasing the concentration of MWCNT-NH2s in composites. The haemostatic evaluation of MWCNT-NH2s/ORC composites on rabbits showed that the aminated MWCNTs increased the rate of blood stopping, decreasing the blood loosing from injured sites.",

keywords = "Cross linking, Functionalized Carbon Nanotubes, Hemostatic effect, Oxidized Regenerated Cellulose",

author = "Chakoli, \{Ali Nabipour\} and Saeed Ahmadi and He, \{Jin Mei\} and Huang, \{Yu Dong\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd.; 2017 INN International Conference/Workshop on Nanotechnology and Nanomedicine, NTNM 2017 ; Conference date: 02-05-2017 Through 03-05-2017",

year = "2018",

doi = "10.1016/j.matpr.2018.04.176",

language = "英语",

volume = "5",

pages = "15661--15666",

journal = "Materials Today: Proceedings",

issn = "2214-7853",

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number = "7",

}

TY - JOUR

T1 - Aminated multiwalled carbon nanotubes/oxidized regenerated cellulose nanocomposites for haemostatic applications

AU - Chakoli, Ali Nabipour

AU - Ahmadi, Saeed

AU - He, Jin Mei

AU - Huang, Yu Dong

PY - 2018

Y1 - 2018

N2 - Commercial surgical absorbable hemostatic agents have been widely applied in various surgeries and played an important role on stopping the bleeding. The commercial Oxidized Regenerated Cellulose (ORC) has also shown several inherent disadvantages. To improve the hemostatic effect of ORC, it has been modified by incorporating aminated MWCNTs (MWCNT-NH2). For modification of neat ORC, the MWCNT-NH2s was reacted with neat ORC. The analytical results revealed a relatively strong interaction existed between aminated MWCNTs and the ORC macromolecules. The hydrophilicity test results revealed significant increment in water uptake of MWCNT-NH2s/ORC composites with increasing the concentration of MWCNT-NH2s in composites. The haemostatic evaluation of MWCNT-NH2s/ORC composites on rabbits showed that the aminated MWCNTs increased the rate of blood stopping, decreasing the blood loosing from injured sites.

AB - Commercial surgical absorbable hemostatic agents have been widely applied in various surgeries and played an important role on stopping the bleeding. The commercial Oxidized Regenerated Cellulose (ORC) has also shown several inherent disadvantages. To improve the hemostatic effect of ORC, it has been modified by incorporating aminated MWCNTs (MWCNT-NH2). For modification of neat ORC, the MWCNT-NH2s was reacted with neat ORC. The analytical results revealed a relatively strong interaction existed between aminated MWCNTs and the ORC macromolecules. The hydrophilicity test results revealed significant increment in water uptake of MWCNT-NH2s/ORC composites with increasing the concentration of MWCNT-NH2s in composites. The haemostatic evaluation of MWCNT-NH2s/ORC composites on rabbits showed that the aminated MWCNTs increased the rate of blood stopping, decreasing the blood loosing from injured sites.

KW - Cross linking

KW - Functionalized Carbon Nanotubes

KW - Hemostatic effect

KW - Oxidized Regenerated Cellulose

UR - https://www.scopus.com/pages/publications/85049232946

U2 - 10.1016/j.matpr.2018.04.176

DO - 10.1016/j.matpr.2018.04.176

M3 - 会议文章

AN - SCOPUS:85049232946

SN - 2214-7853

VL - 5

SP - 15661

EP - 15666

JO - Materials Today: Proceedings

JF - Materials Today: Proceedings

IS - 7

T2 - 2017 INN International Conference/Workshop on Nanotechnology and Nanomedicine, NTNM 2017

Y2 - 2 May 2017 through 3 May 2017

ER -

Aminated multiwalled carbon nanotubes/oxidized regenerated cellulose nanocomposites for haemostatic applications

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Keywords

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