AIE-active theranostic system: selective staining and killing of cancer cells

Chen Gui; Engui Zhao; Ryan T.K. Kwok; Anakin C.S. Leung; Jacky W.Y. Lam; Meijuan Jiang; Haiqin Deng; Yuanjing Cai; Weijie Zhang; Huifang Su; Ben Zhong Tang

doi:10.1039/c6sc04947h

AIE-active theranostic system: selective staining and killing of cancer cells

Chen Gui
, Engui Zhao
, Ryan T.K. Kwok
, Anakin C.S. Leung
, Jacky W.Y. Lam
, Meijuan Jiang
, Haiqin Deng
, Yuanjing Cai
, Weijie Zhang
, Huifang Su
, Ben Zhong Tang^*

^*Corresponding author for this work

Hong Kong University of Science and Technology
South China University of Technology

Research output: Contribution to journal › Article › peer-review

209 Scopus citations

Abstract

Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.

Original language	English
Pages (from-to)	1822-1830
Number of pages	9
Journal	Chemical Science
Volume	8
Issue number	3
DOIs	https://doi.org/10.1039/c6sc04947h
State	Published - 2017
Externally published	Yes

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c6sc04947h

Cite this

@article{3f67b360affa4ec5acc68b096d0726ac,

title = "AIE-active theranostic system: selective staining and killing of cancer cells",

abstract = "Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.",

author = "Chen Gui and Engui Zhao and Kwok, \{Ryan T.K.\} and Leung, \{Anakin C.S.\} and Lam, \{Jacky W.Y.\} and Meijuan Jiang and Haiqin Deng and Yuanjing Cai and Weijie Zhang and Huifang Su and Tang, \{Ben Zhong\}",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c6sc04947h",

language = "英语",

volume = "8",

pages = "1822--1830",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "Royal Society of Chemistry",

number = "3",

}

TY - JOUR

T1 - AIE-active theranostic system

T2 - selective staining and killing of cancer cells

AU - Gui, Chen

AU - Zhao, Engui

AU - Kwok, Ryan T.K.

AU - Leung, Anakin C.S.

AU - Lam, Jacky W.Y.

AU - Jiang, Meijuan

AU - Deng, Haiqin

AU - Cai, Yuanjing

AU - Zhang, Weijie

AU - Su, Huifang

AU - Tang, Ben Zhong

PY - 2017

Y1 - 2017

N2 - Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.

AB - Cancer is the leading cause of death worldwide. With the advantages of low cost, high sensitivity and ease of accessibility, fluorescence imaging has been widely used for cancer detection in the scientific field. Aggregation-induced emission luminogens (AIEgens) are a class of synthesized fluorescent probes with high brightness and photostability in the aggregate state. Herein, a new positively-charged AIEgen, abbreviated as TPE-IQ-2O, is designed and characterized. TPE-IQ-2O not only can distinguish cancer cells from normal cells with high contrast with the aid of the difference in mitochondrial membrane potential as well as the quantity of mitochondria, but it also works as a promising photosensitizer to kill cancer cells through generation of reactive oxygen species upon white light irradiation, thus making it a promising AIE theranostic system.

UR - https://www.scopus.com/pages/publications/85014043485

U2 - 10.1039/c6sc04947h

DO - 10.1039/c6sc04947h

M3 - 文章

AN - SCOPUS:85014043485

SN - 2041-6520

VL - 8

SP - 1822

EP - 1830

JO - Chemical Science

JF - Chemical Science

IS - 3

ER -

AIE-active theranostic system: selective staining and killing of cancer cells

Abstract

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