Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

Shubham Roy; Jingsi Gu; Wujiong Xia; Chao Mi; Bing Guo

doi:10.1016/j.drudis.2024.104101

Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

Shubham Roy
, Jingsi Gu
, Wujiong Xia
, Chao Mi^*
, Bing Guo

^*Corresponding author for this work

Harbin Institute of Technology
Harbin Institute of Technology Shenzhen
Southern University of Science and Technology
Ltd.
Great Bay University

Research output: Contribution to journal › Review article › peer-review

15 Scopus citations

Abstract

This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal–organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.

Original language	English
Article number	104101
Journal	Drug Discovery Today
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.drudis.2024.104101
State	Published - Sep 2024
Externally published	Yes

Keywords

Mn complexes
contrast agents
imaging
magnetic resonance imaging
nanomedicines

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10.1016/j.drudis.2024.104101

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title = "Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions",

abstract = "This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal–organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.",

keywords = "Mn complexes, contrast agents, imaging, magnetic resonance imaging, nanomedicines",

author = "Shubham Roy and Jingsi Gu and Wujiong Xia and Chao Mi and Bing Guo",

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AU - Roy, Shubham

AU - Gu, Jingsi

AU - Xia, Wujiong

AU - Mi, Chao

AU - Guo, Bing

PY - 2024/9

Y1 - 2024/9

N2 - This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal–organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.

AB - This review focuses on the advancements in manganese (Mn) complex-based magnetic resonance imaging (MRI) agents for imaging different diseases. Here we emphasize the unique redox properties of Mn to deliver innovative MRI contrast agents, including small molecules, nanoparticles (NPs), metal–organic frameworks (MOFs), and polymer hybrids. Aspects of their rational design have been discussed, including size dependence, morphology tuning, surface property enhancement, etc., while also discussing the existing challenges and potential solutions. The present work will inspire and motivate scientists to emphasize MRI-guided applications and bring clinical success in the coming years.

KW - Mn complexes

KW - contrast agents

KW - imaging

KW - magnetic resonance imaging

KW - nanomedicines

UR - https://www.scopus.com/pages/publications/85199389112

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DO - 10.1016/j.drudis.2024.104101

M3 - 文献综述

C2 - 39019428

AN - SCOPUS:85199389112

SN - 1359-6446

VL - 29

JO - Drug Discovery Today

JF - Drug Discovery Today

IS - 9

M1 - 104101

ER -

Advancements in manganese complex-based MRI agents: Innovations, design strategies, and future directions

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Keywords

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