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A paper-based device for integrated high-throughput COVID-19 diagnostic tests

  • Hao Sun*
  • , Jianping Zheng
  • , Hui Dong
  • , Yuan Jia
  • *Corresponding author for this work
  • Fuzhou University
  • Fujian Provincial Hospital
  • Southeast University, Nanjing

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Novel microfluidic paper-based analytical devices (μPADs) were developed for qualitatively detecting biological pathogens. 32 reaction units for parallelized nucleic acid analysis were built on a single device. Also, an integrated system including modules of on-chip heating, temperature control, ultraviolet illumination and nucleic acid detection were designed and constructed. We first demonstrated the performance of the devices by detecting synthesized templates using Eiken loop-mediated isothermal amplification (LAMP) kit. Furthermore, the utility of the devices, system and protocols were verified by clinical tests. Multiple samples from COVID-19 cases were concurrently identified within 15 minutes using TianDZ RT-LAMP kit.

Original languageEnglish
Title of host publicationMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
PublisherChemical and Biological Microsystems Society
Pages474-475
Number of pages2
ISBN (Electronic)9781733419017
StatePublished - 2020
Externally publishedYes
Event24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duration: 4 Oct 20209 Oct 2020

Publication series

NameMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
CityVirtual, Online
Period4/10/209/10/20

Keywords

  • COVID-19 Detection
  • Integrated System
  • μPADs

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