A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide

Zhenxing Chi; Rutao Liu; Lingzi Zhao; Pengfei Qin; Xingren Pan; Feng Sun; Xiaopeng Hao

doi:10.1016/j.saa.2008.10.044

A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide

Zhenxing Chi
, Rutao Liu^*
, Lingzi Zhao
, Pengfei Qin
, Xingren Pan
, Feng Sun
, Xiaopeng Hao

^*Corresponding author for this work

Shandong University

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 × 10^-6 g mL^-1 nanoAg and 6.0 × 10^-6 mol L^-1 CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity.

Original language	English
Pages (from-to)	577-581
Number of pages	5
Journal	Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
Volume	72
Issue number	3
DOIs	https://doi.org/10.1016/j.saa.2008.10.044
State	Published - Apr 2009
Externally published	Yes

Keywords

Absorption spectrum
CPB
Genotoxicity
Nucleic acids
Resonance light scattering spectrum
Silver nanoparticle

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10.1016/j.saa.2008.10.044

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title = "A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide",

abstract = "The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 × 10-6 g mL-1 nanoAg and 6.0 × 10-6 mol L-1 CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity.",

keywords = "Absorption spectrum, CPB, Genotoxicity, Nucleic acids, Resonance light scattering spectrum, Silver nanoparticle",

author = "Zhenxing Chi and Rutao Liu and Lingzi Zhao and Pengfei Qin and Xingren Pan and Feng Sun and Xiaopeng Hao",

year = "2009",

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doi = "10.1016/j.saa.2008.10.044",

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volume = "72",

pages = "577--581",

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T1 - A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide

AU - Chi, Zhenxing

AU - Liu, Rutao

AU - Zhao, Lingzi

AU - Qin, Pengfei

AU - Pan, Xingren

AU - Sun, Feng

AU - Hao, Xiaopeng

PY - 2009/4

Y1 - 2009/4

N2 - The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 × 10-6 g mL-1 nanoAg and 6.0 × 10-6 mol L-1 CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity.

AB - The environmental genotoxic behavior of silver nanoparticles (nanoAg) combined with the detergent cetylpyridine bromide (CPB) was examined in vitro. The experimental results showed that the genotoxicity of nanoAg itself is weak, but nanoAg shows obvious genotoxicity after combined with CPB. The combined materials have a strong coeffect on calf thymus DNA (ctDNA) at a concentration of 3.3 × 10-6 g mL-1 nanoAg and 6.0 × 10-6 mol L-1 CPB. After the addition of ctDNA to the nanoAg-CPB system, the particles are scattered and the diameter decreases, which indirectly reveal that nanoAg-CPB has genotoxicity.

KW - Absorption spectrum

KW - CPB

KW - Genotoxicity

KW - Nucleic acids

KW - Resonance light scattering spectrum

KW - Silver nanoparticle

UR - https://www.scopus.com/pages/publications/58549085178

U2 - 10.1016/j.saa.2008.10.044

DO - 10.1016/j.saa.2008.10.044

M3 - 文章

C2 - 19070536

AN - SCOPUS:58549085178

SN - 1386-1425

VL - 72

SP - 577

EP - 581

JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy

IS - 3

ER -

A new strategy to probe the genotoxicity of silver nanoparticles combined with cetylpyridine bromide

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Keywords

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