A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers

Ying Zhang; Jing Ying Liu; Fang Yang; Ya Jing Zhang; Qi Yao; Tie Yu Cui; Xiang Zhao; Zhi Dong Zhang

doi:10.1007/s10856-009-3808-z

A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers

Ying Zhang^*
, Jing Ying Liu
, Fang Yang
, Ya Jing Zhang
, Qi Yao
, Tie Yu Cui
, Xiang Zhao
, Zhi Dong Zhang

^*Corresponding author for this work

CAS - Institute of Metal Research
Shenyang Pharmaceutical University

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

A new strategy for assembling multifunctional nanocomposites with magnetic particles and amino dendrimers was reported. In this strategy, the amino terminated PAMAM G5.0 and Fe₃O₄ NPs prepared by co-deposition method and further modified by aminosilane by two sol-gel processes were combined with the hydrophilic spacer of PEG dicarboxylate by amidation. The nanocomposites were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), atom force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, and hydrophilicity analysis. The results showed that the multifunctional nanocomposites were spherical with the mean diameter of 180 nm and exhibited good dispersion and hydrophilicity. The new strategy put forward here provides an effective route to functionalizing Fe₃O₄ NPs with various amino dendrimers for drug and gene delivery as well as biological detection.

Original language	English
Pages (from-to)	2433-2440
Number of pages	8
Journal	Journal of Materials Science: Materials in Medicine
Volume	20
Issue number	12
DOIs	https://doi.org/10.1007/s10856-009-3808-z
State	Published - Dec 2009
Externally published	Yes

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title = "A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers",

abstract = "A new strategy for assembling multifunctional nanocomposites with magnetic particles and amino dendrimers was reported. In this strategy, the amino terminated PAMAM G5.0 and Fe3O4 NPs prepared by co-deposition method and further modified by aminosilane by two sol-gel processes were combined with the hydrophilic spacer of PEG dicarboxylate by amidation. The nanocomposites were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), atom force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, and hydrophilicity analysis. The results showed that the multifunctional nanocomposites were spherical with the mean diameter of 180 nm and exhibited good dispersion and hydrophilicity. The new strategy put forward here provides an effective route to functionalizing Fe3O4 NPs with various amino dendrimers for drug and gene delivery as well as biological detection.",

author = "Ying Zhang and Liu, \{Jing Ying\} and Fang Yang and Zhang, \{Ya Jing\} and Qi Yao and Cui, \{Tie Yu\} and Xiang Zhao and Zhang, \{Zhi Dong\}",

year = "2009",

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doi = "10.1007/s10856-009-3808-z",

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TY - JOUR

T1 - A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers

AU - Zhang, Ying

AU - Liu, Jing Ying

AU - Yang, Fang

AU - Zhang, Ya Jing

AU - Yao, Qi

AU - Cui, Tie Yu

AU - Zhao, Xiang

AU - Zhang, Zhi Dong

PY - 2009/12

Y1 - 2009/12

N2 - A new strategy for assembling multifunctional nanocomposites with magnetic particles and amino dendrimers was reported. In this strategy, the amino terminated PAMAM G5.0 and Fe3O4 NPs prepared by co-deposition method and further modified by aminosilane by two sol-gel processes were combined with the hydrophilic spacer of PEG dicarboxylate by amidation. The nanocomposites were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), atom force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, and hydrophilicity analysis. The results showed that the multifunctional nanocomposites were spherical with the mean diameter of 180 nm and exhibited good dispersion and hydrophilicity. The new strategy put forward here provides an effective route to functionalizing Fe3O4 NPs with various amino dendrimers for drug and gene delivery as well as biological detection.

AB - A new strategy for assembling multifunctional nanocomposites with magnetic particles and amino dendrimers was reported. In this strategy, the amino terminated PAMAM G5.0 and Fe3O4 NPs prepared by co-deposition method and further modified by aminosilane by two sol-gel processes were combined with the hydrophilic spacer of PEG dicarboxylate by amidation. The nanocomposites were characterized by means of X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS), atom force microscopy (AFM), superconducting quantum interference device (SQUID) magnetometer, and hydrophilicity analysis. The results showed that the multifunctional nanocomposites were spherical with the mean diameter of 180 nm and exhibited good dispersion and hydrophilicity. The new strategy put forward here provides an effective route to functionalizing Fe3O4 NPs with various amino dendrimers for drug and gene delivery as well as biological detection.

UR - https://www.scopus.com/pages/publications/73449139064

U2 - 10.1007/s10856-009-3808-z

DO - 10.1007/s10856-009-3808-z

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SN - 0957-4530

VL - 20

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JO - Journal of Materials Science: Materials in Medicine

JF - Journal of Materials Science: Materials in Medicine

IS - 12

ER -

A new strategy for assembling multifunctional nanocomposites with iron oxide and amino-terminated PAMAM dendrimers

Abstract

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